張孝兵，協(xié)和特聘教授、博導(dǎo)。專注干細胞與基因治療研究30年，發(fā)表論文百余篇，擁有中美發(fā)明專利20項、在審10余項。建立從CRISPRoff/on全基因組篩選到GMP載體生產(chǎn)的完整體系，發(fā)現(xiàn)多種可增強免疫治療的新靶點。入選國家海外高層次領(lǐng)軍人才，獲天津市科技進步一等獎。團隊倡導(dǎo)科研與人文并重，注重學生身心與學業(yè)的全面成長，評為優(yōu)秀教師，鼓勵國際交流，多名學生赴海外深造。
      院校引進人才，2022年加入院校，曾在羅馬琳達大學任副教授。

研究iPSC向MSC、造血及神經(jīng)系統(tǒng)定向分化，探索基因編輯與體內(nèi)細胞治療新策略。建立非整合重編程與高保真編輯體系，在血友病A和地中海貧血等基因治療上取得突破；自主開發(fā)LNP/VLP體內(nèi)遞送平臺，結(jié)合納米抗體靶向，實現(xiàn)HSC與T細胞精準編輯；通過AI與多組學算法發(fā)掘治療新靶點。更多成果見B站頻道《基因畫卷與細胞詩篇》：https://space.bilibili.com/3546556473019252。以國際化科研氛圍和高效協(xié)作機制，鼓勵學生從基礎(chǔ)到轉(zhuǎn)化、從實驗到生信，成長為細胞基因治療領(lǐng)域的未來領(lǐng)軍人才。

久久综合九色欧美综合狠狠_伊人热热久久原色播放WWW_成A人片亚洲日本久久_久久不见久久见免费影院www日本_97久久精品人人做人人爽,又色又爽又黄的视频在线观看,狼群影院视频在线观看高清版,亚洲AV无码精品网站性色,国产乱码久久久久久红粉影视,精品国产乱码久久久久久一区二区,国产精品免费视频网站,国产A级毛片久久久久久精品,一级特黄高清aaaa大片,亚洲中文字幕欧美一区,久久精品国产99久久狂热,黑人巨大精品欧美_黑人巨大精品欧美黑寡妇_黑人巨大精品欧美一区二区_黑人巨大精品欧美一区二区免费_黑人巨大跨种族video_黑人巨大无码中文字幕无码_黑人巨茎大战俄罗斯美女_黑人巨茎大战俄罗斯美女,中文字幕av不卡|亚洲欧美国产另类|天天干在线播放|日韩黄视频|欧美七区|可以免费看毛片的网站|黄色片在线|国产精品96久久久久久

1．Zhao JJ#, Tian SN#, Peng ZY#, Ren JX, Zhang YY, Li GH, Deng DH, Zhang JP*, Zhang XB*. Biomembrane-inspired lipid nanoparticles enhance CRISPR-Cas9 editing for hemophilia A. J Control Release. 2025 Aug 18:114141. (IF: 11.500)

2．Yang Z#, Fu Y, # Zhao J#, Zhang F, Li S, Zhao M, Wen W, Zhang L, Cheng T, Zhang J*, Zhang X*. Superior Fidelity and Distinct Editing Outcomes of SaCas9 Compared to SpCas9 in Genome Editing. Genomics Proteomics Bioinformatics. 2023 Dec;21(6):1206-1220. (IF: 9.500)

3．Quan ZJ#, Li SA#, Yang ZX, Zhao JJ, Li GH, Zhang F, Wen W*, Cheng T*, Zhang XB*. GREPore-seq: A robust workflow to detect changes after gene editing through long-range PCR and nanopore sequencing. Genomics Proteomics Bioinformatics. 2023 Dec;21(6):1221-1236. (IF: 9.500)

4．Pei YA#, Mikaeiliagah E#, Wang B, Zhang X*, Pei M*. The matrix microenvironment influences but does not dominate tissue-specific stem cell lineage differentiation. Mater Today Bio. 2023;23:100805. Published 2023 Sep 16. (IF: 8.680)

5．Wen W#, Quan ZJ#, Li SA#, Yang ZX, Fu YW, Zhang F, Li GH, Zhao M, Ying MD, Xu J, Zhang JP, Cheng T*, Zhang XB*. Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion. Genome biology. 2021 Aug 20;22(1):236. (IF: 17.906)

6．Fu YW#, Dai XY#, Wang WT#, Yang ZX, Zhao JJ, Zhang JP, Wen W, Zhang F, Kerby C. Oberg, Zhang L*,Cheng T*, Zhang XB*. Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ,MMEJ and HDR editing. Nucleic Acids Research, 2021 Jan 25;49(2):969-985. (IF: 19.160)

7．Wang Y#, Hu G#, Hill RC#, Dzieciatkowska M, Hansen KC, Zhang XB*, Yan Z*, Pei M*. Matrix reverses immortalization-mediated stem cell fate determination. Biomaterials. 2020 Sep 16;265:120387. (IF: 12.479)

8．Zhang JP#, Cheng XX#, Zhao M#, Li GH#, Xu J#, Zhang F, Yin MD, Meng FY, Dai XY, Fu YW, Yang ZX, Arakaki C, Su RJ, Wen W, Wang WT, Chen W, Choi H, Wang C, Gao G, Zhang L, Cheng T*, Zhang XB*. Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse. Genome Biology. 2019 Dec 16;20(1):276. (IF: 10.806)

9．Li XL#, Li GH#, Fu J#, Fu YW, Zhang L, Chen WQ, Arakaki C, Zhang JP, Wen W, Botimer GD, Baylink D, Aranda L, Choi H, Bechar R, Talbot P, Sun CK*, Cheng T*, Zhang XB*. Highly-efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by BCL-XL. Nucleic Acids Research, 2018 Nov 2;46(19):10195-10215. (IF: 11.147)

10．Zhang JP#, Li XL#, Li GH, Chen W, Arakaki C, Botimer GD, Baylink D, Zhang L, Wen W, Fu YW, Xu J, Chun N, Yuan W, Cheng T*, Zhang XB*. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated dsDNA cleavage. Genome Biology. 2017 Feb 20;18(1):35. (IF: 13.214，C100)