蘭雨，研究員，博士生導師。“國家高層次人才計劃”入選者、“珠江人才計劃”領軍人才。成果曾獲《國家自然科學二等獎》（2012）、入選《中國2020年度重要醫學進展》、《2022 Sanofi-細胞研究杰出論文獎》、《國家“十三五”科技創新成就展》、《中國血液學年度十大研究進展》(2020/2021/2022/2024)。承擔國家重點研發計劃課題、國家自然科學基金重大項目課題等項目。
      院校引進人才，2025年加入院校，曾任暨南大學血液學研究所所長、再生醫學教育部重點實驗室副主任。

研究方向聚焦血管與造血系統發育的譜系規律及調控機制。系列研究揭秘哺乳動物胚胎血管及造血系統的異質性細胞群體及發育路徑、發現胚胎最早和廣泛發生的靜脈動脈命運轉換、揭示造血干細胞形成的系列調控新機制。通訊作者（含共同）研究論文發表在Nature、Cell Stem Cell、Cell Res(x5)、Dev Cell(x2)、Immunity、Nat Immunol、Blood(x2)等高水平期刊。其中3篇封面論文、5篇被F1000推薦、6篇獲同期專文評述、1篇ESI高被引論文。

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1．Haizhen Wang#, Di Liu#, Haifeng Chen#, Yuqing Jiao, Haixin Zhao, Zongcheng Li, Siyuan Hou, Yanli Ni, Rong Zhang, Jinyong Wang, Jie Zhou*, Bing Liu*, Yu Lan*. Nupr1 Negatively Regulates Endothelial to Hematopoietic Transition in the Aorta-Gonad-Mesonephros Region. Adv Sci. 2023 Feb;10(6):e2203813. (IF2023=14.13)

2．Siyuan Hou#, Zongcheng Li#, Ji Dong#, Yun Gao#, Zhilin Chang#, Xiaochen Ding#, Shuaili Li, Yunqiao Li, Yang Zeng, Qian Xin, Baihan Wang, Yanli Ni, Xiaowei Ning, Yuqiong Hu, Xiaoying Fan, Yu Hou, Xianlong Li, Lu Wen, Bin Zhou, Bing Liu*, Fuchou Tang*, Yu Lan*. Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. Cell Res. 2022 Apr;32(4):333-348. (IF2022=44.1, 同期專文評述)

3．Xianlong Li#, Di Liu#, Linlin Zhang, Haizhen Wang, Yunqiao Li, Zongcheng Li, Aibin He, Bing Liu, Jie Zhou*, Fuchou Tang*, Yu Lan*. The comprehensive DNA methylation landscape of hematopoietic stem cell development. Cell Discov. 2021 Sep 21;7(1):86. (IF2021=38.079)

4．Zhilei Bian#, Yandong Gong#, Tao Huang#, Christopher Z. W. Lee#, Lihong Bian#, Zhijie Bai#, Hui Shi#, Yang Zeng, Chen Liu, Jian He, Jie Zhou, Xianlong Li, Zongcheng Li, Yanli Ni, Chunyu Ma, Lei Cui, Rui Zhang, Jerry K. Y. Chan, Lai Guan Ng, Yu Lan*, Florent Ginhoux*, Bing Liu*. Deciphering Human Macrophage Development at Single Cell Resolution. Nature. 2020 Jun;582(7813):571-576. (IF2020=49.962, F1000, ESI高被引論文, C100)

5．Siyuan Hou#, Zongcheng Li#, Xiaona Zheng#, Yun Gao#, Ji Dong#, Yanli Ni#, Xiaobo Wang, Yunqiao Li, Xiaochen Ding, Zhilin Chang, Shuaili Li, Yuqiong Hu, Xiaoying Fan, Yu Hou, Lu Wen, Bing Liu*, Fuchou Tang*, Yu Lan*. Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses. Cell Res. 2020 May;30(5):376-392. (IF2020=25.617, 同期專文評述)

6．Yang Zeng#, Chen Liu#, Yandong Gong#, Zhijie Bai#, Siyuan Hou#, Jian He, Zhilei Bian, Zongcheng Li, Yanli Ni, Jing Yan, Tao Huang, Hui Shi, Chunyu Ma, Xueying Chen, Jinyong Wang, Lihong Bian, Yu Lan*, Bing Liu*, Hongbo Hu*. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity. 2019 Nov 19;51(5):930-948.e6. (IF2019=22.553, 同期專文評述)

7．Yang Zeng#, Jian He#, Zhijie Bai#, Zongcheng Li#, Yandong Gong, Chen Liu, Yanli Ni, Junjie Du, Chunyu Ma, Lihong Bian, Yu Lan*, Bing Liu*. Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing. Cell Res. 2019 Nov;29(11):881-894. (IF2019=20.507, F1000, C100)

8．Jie Zhou#, Jiayue Xu#, Linlin Zhang#, Siqi Liu#, Yanni Ma#, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined single-cell profiling of lncRNAs and functional screening reveals H19 is pivotal for embryonic hematopoietic stem cell development. Cell Stem Cell. 2019 Feb 7;24(2):285-298.e5. (IF2019=20.860, F1000)

9．Hui Ye#, Xiaobo Wang#, Zongcheng Li, Fan Zhou, Xianlong Li, Yanli Ni, Weijing Zhang, Fuchou Tang, Bing Liu*, Yu Lan*. Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence. Cell Res. 2017 Aug;27(8):1065-1068. (IF2017=15.393, F1000)

10．Fangfei Li#, Yu Lan#,*, Youliang Wang#, Jun Wang, Guan Yang, Fanwei Meng, Hua Han, Anming Meng, Yaping Wang, Xiao Yang*. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell. 2011 Mar 15;20(3):291-302. (IF2011=14.03, 同期專文評述, F1000, C100)