黃海洪，1967年生，籍貫江蘇泗洪，藥物化學家，藥物研究所所研究員，博士生導師。1985年考入北京師范大學化學專業，1989年獲得學士學位。1989年在南開大學物理有機化學專業攻讀碩士學位，從事芳香有機鋰試劑與鹵代烴的反應機理研究。2009-2010年在美國特拉華大學化學系做訪問學者，主要研究活性天然產物的全合成和結構優化工作。1992年進入藥物研究所，主要從事新藥研究工作。1995年升為助理研究員。1998年為副研究員。2004年為研究員。

v針對重大疾病耐藥結核、惡性腫瘤、代謝性疾病及炎癥免疫等治療領域的創新藥物研究，涉及藥物分子設計與合成、活性天然產物的結構優化、新藥研發項目的跨學科綜合管理。

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1.Hongyi Zhao#, Yongxin Gao#, Wei Li#, Li Sheng#, Keli Cui, Bin Wang, Lei Fu, Meng Gao, Ziyun Lin, Xiaowen Zou, Mary Jackson, Haihong Huang*, Yu Lu*, and Dongfeng Zhang*. Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis. J. Med. Chem., 2022, 65(15):10534?10553. (IF=8.039)

2. Rongfei Qin#, Pengxu Wang#, Bin Wang, Lei Fu, Sarah M. Batt, Gurdyal S. Besra, Chengwei Wu, Yanan Wang, Haihong Huang*, Yu Lu*, and Gang Li*. Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant. Eur. J. Med. Chem., 2022, 231, 114145. (IF=7.088)

3. Yongqi Wu, Bin Wang, Haijia Lu, Hongyi Zhao, Beibei Yang, Yu Lu, Dongfeng Zhang*, Ning Sun*, and Haihong Huang*. Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens. J. Med. Chem., 2021, 64(6):3234?3248. (IF=8.039)

4. Pengxu Wang#, Sarah M. Batt#, Bin Wang, Lei Fu, Rongfei Qin, Yu Lu, Gang Li*, Gurdyal S. Besra*, and Haihong Huang*. Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities. J. Med. Chem., 2021, 64(9):6241?6261. (IF=8.039)

5.Dongfeng Zhang#, Peng Li#, Yongxin Gao, Yaoyao Song, Yaqin Zhu, Hong Su, Beibei Yang, Li Li, Gang Li, Ningbo Gong, Yang Lu, Huanjie Shao*, Chunrong Yu*, Haihong Huang*. Discovery of a Candidate Containing an (S)?3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro?1H?inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia. J. Med. Chem., 2021, 64(11):7434?7452. (IF=8.039)

6. Hongyi Zhao, Bin Wang, Lei Fu, Gang Li, Haijia Lu, Yuke Liu, Li Sheng, Yan Li, Baoxi Zhang, Yang Lu, Chen Ma, Haihong Huang*, Dongfeng Zhang* and Yu Lu*. Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis. J. Med. Chem., 2020, 63(17):9316?9339. (IF=7.446)

7. Peng Li, Bin Wang, Gang Li, Lei Fu, Dongfeng Zhang, Ziyun Lin, Haihong Huang*, and Yu Lu*. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur. J. Med. Chem., 2020, 206, 112538. (IF=6.514)

8.Gang Li#, Bingxu Meng#, Baokun Yuan, Yi Huan, Tian Zhou, Qian Jiang, Lei Lei, Li Sheng, Weiping Wang, Ningbo Gong, Yang Lu, Chen Ma, Yan Li, Zhufang Shen*, and Haihong Huang*. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur. J. Med. Chem., 2020, 188, 112017. (IF=6.514)

9. Peng Li, Bin Wang, Xinwei Zhang, Sarah M. Batt, Gurdyal S. Besra, Tingting Zhang, Chen Ma, Dongfeng Zhang, Ziyun Lin, Gang Li*, Haihong Huang*, and Yu Lu*. Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones. Eur. J. Med. Chem., 2018, 160, 157?170. (IF=4.833)

10. Dongfeng Zhang#, Yu Lu#, Kai Liu, Binna Liu, Jingbin Wang, Gang Zhang, Hao Zhang, Yang Liu, Bin Wang, Meiqin Zheng, Lei Fu, Yanyan Hou, Ningbo Gong, Yang Lv, Chun Li, Christopher B. Cooper, Anna M. Upton, Dali Yin, Zhenkun Ma* and Haihong Huang*. Identification of Less Lipophilic Riminophenazine Derivatives for the Treatment of Drug-Resistant Tuberculosis. J. Med. Chem., 2012, 55(19):8409?8417. (IF=5.614)