司書(shū)毅，1961年生，籍貫山東淄博，微生物藥物學(xué)家，醫(yī)藥生物技術(shù)研究所研究員，博士生導(dǎo)師。1982年獲中國(guó)藥科大學(xué)藥化專(zhuān)業(yè)學(xué)士學(xué)位。1989年、1999年獲中國(guó)協(xié)和醫(yī)科大學(xué)微生物藥學(xué)碩士學(xué)位、微生物與生化藥學(xué)博士學(xué)位。1995年赴日本北里研究所，1997年在東京理科大學(xué)綜合研究所，2005年公派赴日本RIKEN橫濱研究所，2007年赴美國(guó)Oregon國(guó)立大學(xué)等從事天然產(chǎn)物及蛋白質(zhì)化學(xué)相關(guān)研究。

創(chuàng)新微生物藥物篩選與發(fā)現(xiàn)研究，抗感染藥物發(fā)現(xiàn)研究，抗代謝性疾病藥物發(fā)現(xiàn)研究

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1. H. Sun#, X. Li#, M. Chen, M#. Zhong, Y. Li, K. Wang, Y. Du, X. Zhen, R. Gao, Y. Wu, Y. Shi, L. Yu, Y. Che, Y. Li*, J-D. Jiang*, B. Hong*, S. Si*, Multi-omics-guided discovery of omicsynins produced by Streptomyces sp. 1647: pseudo-tetrapeptides active against influenza a viruses and coronavirus HCoV-229E, Engineering (2022), doi.org/10.1016/j.eng.2021.05.010, In press (IF=12.834)

2. Junxia Wang#, Minghua Chen#, Mengyan Wang, Wenxia Zhao, Conghui Zhang, Xiujun Liu, Meilian Cai, Yuhan Qiu, Tianshu Zhang,Huimin Zhou, Wuli Zhao*, Shuyi Si* and Rongguang Shao*,The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells, Acta Pharm Sin B, 2022;12(1):210-227, (IF=14.911)

3. Yanni Xu#, Chang Liu# , Xiaowan Han#, Xiaojian Jia, Yongzhen Li, Chao Liu, Ni Li, Lunming Liu, Peng Liu, Xinhai Jiang, Weizhi Wang, Xiao Wang, Yining Li, Mingzhu Chen, Jinque Luo, Xuan Zuo, Jiangxue Han, Li Wang, Yu Du, Yang Xu, Jian-Dong Jiang*, Bin Hong *, Shuyi Si*. E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e284-e298. (IF=8.331)

4. Xiaoli Zhao#, Shuai Lin, Huiyi Li, Shuyi Si*, Zhen Wang*, Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level, J Bone Miner Res. 2021 Mar; 36(3): 591–603. (IF=6.741)

5. Dongsheng Li#, Chao Liu#, Xinhai Jiang,Yuan Lin,Jing Zhang,Yan Li,Xuefu You,Wei Jiang,Minghua Chen*,Yanni Xu*,Shuyi Si*, Design, Synthesis, and Evaluation of Substituted 2-acylamide-1,3-benzo[d]zole Analogues as Agents against MDR- and XDR-MTB,European Journal of Medicinal Chemistry, 2020, 10.10    (IF= 6.514)

6. Minghua Chen#, Renzhong Wang#, Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan*, Feng Feng*, Shuyi Si*. Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp. Organic Letters, 2019, 21 (5), 1530-1533. (IF=6.555)

7. Wang W#, Liu C, Zhu N, Lin Y, Jiang J, Wang Y, Li Y, Si S. Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10.Acta Pharm Sin B. 2018 Sep;8(5):772-783.(IF=6.014)

8. Zhu N#, Lin Y#, Li D, Gao N, Liu C, You X, Jiang J, Jiang W*, Si S*, Identification of an anti-TB compound targeting the tyrosyl-tRNA synthetase. J Antimicrob Chemother. 2015 Aug. 70(8): 2287-94 (IF=5.313)

9. Yuan Lin#, Yan Li#, Yuanjun Zhu, Jing Zhang, Yongzhen Li, Xiao Liu, Wei Jiang, Shishan Yu, Xuefu You, Chunling Xiao, Bin Hong, Yanchang Wang,* Jiandong Jiang,* Shuyi Si,* "Identification of anti-tuberculosis agents that target ribosome subunit interaction using yeast two-hybrid system, PNAS, 2012, 109(43):17424-17429(IF=9.681)

10. Guo HF#, Shao HY, Yang ZY, Xue ST, Li X, Liu ZY, He XB, Jiang JD, Zhang YQ, Si SY*, Li ZR*, Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats, J Med Chem. 2010 Feb 25; 53(4):1819-29.(IF=5.207)