焦宇辰，中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院研究員，博士生導(dǎo)師。1995年北京大學(xué)生命科學(xué)院協(xié)和醫(yī)學(xué)預(yù)科，2003年在中國協(xié)和醫(yī)科大學(xué)八年制臨床醫(yī)學(xué)專業(yè)獲醫(yī)學(xué)博士(MD)學(xué)位，2009年在Johns Hopkins大學(xué)獲生物化學(xué)博士(PhD)學(xué)位。2010年進(jìn)入Johns Hopkins大學(xué)Ludwig癌癥研究所進(jìn)行博士后研究，主要研究腫瘤基因組。2013年加入中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院，從事腫瘤基礎(chǔ)及轉(zhuǎn)化研究。

基于多種組學(xué)及生物信息學(xué)分析腫瘤分子改變時(shí)空異質(zhì)性及腫瘤分子分型；基于CRISPR-Cas9協(xié)同致死篩選的功能基因組研究，發(fā)現(xiàn)針對(duì)驅(qū)動(dòng)基因突變的新靶點(diǎn)、新藥物；基于ctDNA多組學(xué)標(biāo)志物的腫瘤液體活檢技術(shù)在腫瘤早篩和療效評(píng)估的應(yīng)用。

久久综合九色欧美综合狠狠_伊人热热久久原色播放WWW_成A人片亚洲日本久久_久久不见久久见免费影院www日本_97久久精品人人做人人爽,又色又爽又黄的视频在线观看,狼群影院视频在线观看高清版,亚洲AV无码精品网站性色,国产乱码久久久久久红粉影视,精品国产乱码久久久久久一区二区,国产精品免费视频网站,国产A级毛片久久久久久精品,一级特黄高清aaaa大片,亚洲中文字幕欧美一区,久久精品国产99久久狂热,黑人巨大精品欧美_黑人巨大精品欧美黑寡妇_黑人巨大精品欧美一区二区_黑人巨大精品欧美一区二区免费_黑人巨大跨种族video_黑人巨大无码中文字幕无码_黑人巨茎大战俄罗斯美女_黑人巨茎大战俄罗斯美女,中文字幕av不卡|亚洲欧美国产另类|天天干在线播放|日韩黄视频|欧美七区|可以免费看毛片的网站|黄色片在线|国产精品96久久久久久

1. Wang P#, Song Q#, Ren J#, Zhang W#, Wang Y, Zhou L, Wang D, Chen K, Jiang L, Zhang B, Chen W, Qu C*, Zhao H*, Jiao Y*. Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection. Science Translational Medicine. 2022;14(672): eabp8704. (IF=19.319)

2. Ma Y#, Zhu Q#, Wang X#, Liu M, Chen Q, Jiang L, Chi Y, Zeng YX*, Zhao H*, Jiao Y*. Synthetic lethal screening identifies DHODH as a target for MEN1-mutated tumor cells. Cell Research. 2022, 32(6):596-599. (IF=46.297)

3. Zhao D#, Yue P#, Wang T#, Wang P#, Song Q, Wang J, Jiao Y*. Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer. Journal of Hematology Oncology. 2021, 14(1):164. (IF=23.168)

4. Fujikura K#, Hosoda W#, Felsenstein M#, Song Q#, Reiter JG,  Zheng L, Beleva Guthrie V, Rincon N, Dal Molin M, Dudley J, Cohen JD, Wang P, Fischer CG, Braxton AM, No? M, Jongepier M, Fernández-Del Castillo C, Mino-Kenudson M, Schmidt CM, Yip-Schneider MT, Lawlor RT, Salvia R, Roberts NJ, Thompson ED, Karchin R, Lennon AM, Jiao Y*, Wood LD*. Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions. Gut. 2021, 70(5):928-939. (IF=31.793)

5. Zhu Q#, Ma Y#, Wei Z#, Li M, Zhang Y, Liu M, He H, Qu C, Cai J, Wang X*, Zeng Y*, Jiao Y*. AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Signal Transduction Targeted Therapy. 2021, 6(1):299. (IF=38.104)

6. Liang J#, Zhao H#, Diplas BH#, Liu S#, Liu J, Wang D, Lu Y, Zhu Q, Wu J, Wang W, Yan H, Zeng YX*, Wang X*, Jiao Y*. Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. Cancer Research. 2020, 80(3):510-523. (IF=12.701)

7. Qu C#*, Wang Y#, Wang P#, Chen K#, Wang M#, Zeng H#, Song Q, Diplas BH, Tan D, Fan C, Guo Q, Zhu Z, Yin H, Jiang L, Chen X, Zhao H, He H, Wang Y, Li G, Bi X, Zhao X, Chen T, Tang H, Lv C, Wang D, Chen W, Zhou J, Zhao H, Cai J, Wang X, Wang S, Yan H, Zeng YX, Cavenee WK*, Jiao Y*. Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy. Proc Natl Acad Sci U S A. 2019, 116(13):6308-6312. (IF=9.412)

8. Huang J*, Xu B*, Mo H, Zhang W, Chen X, Wu D, Qu D, Wang X, Lan B, Yang B, Wang P, Zhang H, Yang Q, Jiao Y*. Safety, activity and biomarkers of SHR-1210, an anti-PD-1 antibody, for patients with advanced esophageal carcinoma. Clinical Cancer Research. 2018, 24(6):1296-1304. (IF=8.911, C100)

9. Zhang W#, He H#, Zang M#, Wu Q#, Zhao H#, Lu L#, Ma P, Zheng H, Wang N, Zhang Y, He S, Chen X, Wu Z, Wang X, Cai J, Liu Z, Sun Z, Zeng YX*, Qu C*, Jiao Y*, Genetic Features of Aflatoxin-associated Hepatocellular Carcinomas. Gastroenterology. 2017, 153(1):249-262. (IF=20.773)

10. Jiao Y#, Shi C#, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA Jr, Vogelstein B*, Kinzler KW*, Hruban RH*, Papadopoulos N*. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011, 331(6021):1199-203. (IF=31.201, C100, ESI, R)