張宏冰，1962年生，籍貫湖北，腫瘤生物學(xué)家，基礎(chǔ)醫(yī)學(xué)研究所研究員，博士生導(dǎo)師。1978年考入三峽大學(xué)臨床醫(yī)學(xué)專業(yè)，1982年獲得學(xué)士學(xué)位。1985年在華中科技大學(xué)同濟(jì)醫(yī)學(xué)院外科專業(yè)攻讀碩士學(xué)位，從事心血管病研究。1990年在賓夕法尼亞大學(xué)醫(yī)學(xué)院病理學(xué)專業(yè)攻讀博士學(xué)位，從事腫瘤研究。1998年進(jìn)入NIH、哈佛大學(xué)醫(yī)學(xué)院Brigham & Women’s 醫(yī)院、DFCI研究所進(jìn)行博士后研究工作，2004-2005年為講師，主要研究腫瘤的發(fā)生機(jī)制與治療。自2006年為中國(guó)醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所-北京協(xié)和醫(yī)學(xué)院基礎(chǔ)學(xué)院教授。

從結(jié)節(jié)性硬化癥、心肌病等罕見(jiàn)疾病到肝癌等常見(jiàn)疾病，探索雷帕霉素靶蛋白（mTOR）信號(hào)傳導(dǎo)通路調(diào)節(jié)與疾病發(fā)生的機(jī)制和靶向治療。針對(duì)疑難重癥及罕見(jiàn)病，用mTOR抑制劑雷帕霉素（西羅莫司）老藥新用開展多項(xiàng)臨床試驗(yàn)。

久久综合九色欧美综合狠狠_伊人热热久久原色播放WWW_成A人片亚洲日本久久_久久不见久久见免费影院www日本_97久久精品人人做人人爽,又色又爽又黄的视频在线观看,狼群影院视频在线观看高清版,亚洲AV无码精品网站性色,国产乱码久久久久久红粉影视,精品国产乱码久久久久久一区二区,国产精品免费视频网站,国产A级毛片久久久久久精品,一级特黄高清aaaa大片,亚洲中文字幕欧美一区,久久精品国产99久久狂热,黑人巨大精品欧美_黑人巨大精品欧美黑寡妇_黑人巨大精品欧美一区二区_黑人巨大精品欧美一区二区免费_黑人巨大跨种族video_黑人巨大无码中文字幕无码_黑人巨茎大战俄罗斯美女_黑人巨茎大战俄罗斯美女,中文字幕av不卡|亚洲欧美国产另类|天天干在线播放|日韩黄视频|欧美七区|可以免费看毛片的网站|黄色片在线|国产精品96久久久久久

<dfn id="add4d"><fieldset id="add4d"></fieldset></dfn>

1. Liu F#, Gai X#, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L*, Zhang H*. Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2202157119. (IF=12.779)

2. Zhou J#, Zhao Z#, Sun T#, Liu W, Yu Z, Liu J, Yu Y, Ning S*,Zhang H*. Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study. Am J Gastroenterol. 2021 May 1;116(5):1044-1052. (IF= 12.045)

3. Chen X, # Wang Y#, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H, Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H*. mTORC1Upregulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice. Gastroenterology. 2015 Sep;149(3):741-52.e14. (IF=33.883)

4. Sun Q^#, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski DJ, Zhang H*. Mammalian target of rapamycin upregulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 2011 Mar 8;108(10):4129-34. (IF=12.779) (C100, F1000)

5. Zha X^#, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H*. Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis. Cancer Res. 2011 Jan 1;71(1):13-8. (IF=13.312) (C100)

6. Mao Y^#*, Yang H, Xu H, Lu X, Sang X, Du S, Zhao H, Chen W, Xu Y, Chi T, Yang Z, Cai J, Li H, Chen J, Zhong S, Mohanti SR, Lopez-Soler R, Millis JM, Huang J, Zhang H. Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma. Gut. 2010 Dec;59(12):1687-93. (IF=31.793) (C100)

7. Ma J^#, Meng Y^#, Kwiatkowsk DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, Zhang S, Chen R, Wang L, Wu E, Cai G, Malinowska-Kolodziej I, Liao Q, Liu Y, Zhao Y, Sun Q, Xu K, Dai J, Han J, Wu L, Zhao RC, Shen H, Zhang H*. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest. 2010, 120: 103-14. (IF=19.456) (C100)

8. Zhang H^#*, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. PDGF receptors are critical for PI3K/AKT activation and negatively regulated by mTOR. J Clin Invest. 2007 Mar;117(3):730-8. (IF= 19.456) (C100)

9. Zhang H^#, Cicchetti G, Onda H, Koon HB, Asrikan K, Bajraszewski N, Vazquez P. Carpenter C, Kwiatkowski DJ.* Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signalling through downregulation of PDGFR. J Clin Invest. 2003 Oct;112(8):1223-33. (IF=19.456) (C100, F1000)

10. Kwiatkowski DJ^#*, Zhang H, Bandura JL, Heiberger KM, Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet. 2002 Mar 1;11(5):525-34. (IF=5.121) (C100)