劉德培，1950年生，安徽阜南人，生物化學(xué)與分子生物學(xué)家，基礎(chǔ)醫(yī)學(xué)研究所研究員，博士生導(dǎo)師。1978年在湖南醫(yī)科大學(xué)生物化學(xué)專(zhuān)業(yè)攻讀碩士學(xué)位，從事生物化學(xué)研究。1984年在中國(guó)協(xié)和醫(yī)科大學(xué)生物化學(xué)與分子生物學(xué)專(zhuān)業(yè)攻讀博士學(xué)位，從事珠蛋白基因調(diào)控研究。1987年進(jìn)入美國(guó)加州大學(xué)舊金山分校進(jìn)行博士后研究工作，主要研究珠蛋白基因表達(dá)調(diào)控和基因治療。1987年升為助理研究員，1989年為升副研究員，1992年升為研究員。

主要從事基因表達(dá)調(diào)控、基因治療與心血管疾病發(fā)病機(jī)制研究。在深入研究疾病個(gè)性機(jī)制的基礎(chǔ)上，運(yùn)用系統(tǒng)性研究新思路新方法，探索重大疾病發(fā)生發(fā)展的共性危險(xiǎn)因素和共性機(jī)制，為疾病防控提出干預(yù)的新策略。

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1. Jian-Fei Pei#,Xun-Kai Li#,Wen-Qi Li#, Qian Gao, Yang Zhang, Xiao-Man Wang, Jia-Qi Fu, Shen-Shen Cui, Jia-Hua Qu, Xiang Zhao, De-Long Hao, Dapeng Ju, Na Liu, Kate S Carroll,Jing Yang, Eric Erquan Zhang,Ji-Min Cao,Hou-Zao Chen*,De-Pei Liu*.Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks.Nat Cell Biol. 2019 Dec;21(12):1553-1564. (IF=28.824)

2. Yu-Xuan Luo#, Xiaoqiang Tang#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity.Eur Heart J.2017 May 7;38(18):1389-1398. (IF=29.983，C100)

3. Yue Liu#, Ting-Ting Wang#, Ran Zhang#, Wen-Yan Fu, Xu Wang, Fang Wang, Peng Gao, Yang-Nan Ding, Yan Xie, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.Calorie restriction protects against experimental abdominal aortic aneurysms in mice.J Exp Med. 2016 Oct 17;213(11):2473-2488. (IF=14.307)

4. Hou-Zao Chen#, Fang Wang#, Peng Gao#, Jian-Fei Pei#, Yue Liu, Ting-Ting Xu, Xiaoqiang Tang, Wen-Yan Fu, Jie Lu, Yun-Fei Yan, Xiao-Man Wang, Lei Han, Zhu-Qin Zhang, Ran Zhang, Ming-Hui Zou, De-PeiLiu*.Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.Circ Res.2016 Oct 28;119(10):1076-1088. (IF=17.367, C100)

5. Guo-You Liu#, Guang-Nian Zhao#, Xiao-Feng Chen, De-Long Hao, Xiang Zhao, Xiang Lv*, De-Pei Liu*.The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster.Nucleic Acids Res. 2016 Apr 7;44(6):2613-27. (IF=16.971)

6. Ran Zhang#, Hou-Zao Chen*, De-Pei Liu*.The Four Layers of Aging.Cell Syst. 2015 Sep 23;1(3):180-6. (IF=10.304)

7. Jie Wu#, Li-Quan Zhou#, Wei Yu#, Zhi-Guo Zhao, Xue-Min Xie, Wen-Tian Wang, Jian Xiong, Man Li, Zheng Xue, Xing Wang, Peng Zhang, Bei-Bei Mao, De-Long Hao, Xiang Lv*, De-Pei Liu*.PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1.Blood. 2014 Jan 9;123(2):261-70. (IF=22.113)

8. Li Li#, Hui-Na Zhang#, Hou-Zao Chen#, Peng Gao, Li-Hua Zhu, Hong-Liang Li, Xiang Lv, Qing-Jun Zhang, Ran Zhang, Zhao Wang, Zhi-Gang She, Ran Zhang, Yu-Sheng Wei, Guan-Hua Du, De-Pei Liu*, Chih-Chuan Liang.SIRT1 acts as a modulator of neointima formation following vascular injury in mice.Circ Res. 2011 May 13;108(10):1180-9. (IF=17.367)

9. Shuang Zhou# , Hou-Zao Chen#, Yan-Zhen Wan#, Qing-Jun Zhang, Yu-Sheng Wei, Shuai Huang, Jin-Jing Liu, Yun-Biao Lu, Zhu-Qin Zhang, Rui-Feng Yang, Ran Zhang, Hua Cai, De-Pei Liu*, Chih-Chuan Liang.Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.Circ Res.2011 Sep 2;109(6):639-48. (IF=17.367)

10.Zhi-Gang She#, Wei Zheng, Yu-Sheng Wei, Hou-Zao Chen, Ai-Bing Wang, Hong-Liang Li, Guang Liu, Ran Zhang, Jin-Jing Liu, William B Stallcup, Zhongjun Zhou, De-Pei Liu*, Chih-Chuan Liang.Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice.Circ Res. 2009 May 22;104(10):1160-8. (IF=17.367)