張抒揚，1963年生，現任中國醫學科學院北京協和醫院（臨床醫學研究所）院（所）長、黨委副書記，中國醫學科學院北京協和醫學院副院校長、黨委常委（兼）。心血管內科學教授，主任醫師，博士生導師。1980年考入北京醫科大學醫學專業，獲學士學位。1986年在中國協和醫科大學內科學心血管學專業攻讀博士學位，從事臨床醫學專業研究。1995年進入美國路易斯安那州新奧爾良市AltonOchsner心血管研究院心臟科進行博士后研究工作，主要研究心血管及疑難罕見疾病的發病機制、臨床診療及新藥研發。1999年升為副主任醫師。2005年升為主任醫師。

冠心病、高血壓、血脂異常等慢病綜合管理與防治；心肌病和各種原因導致的心力衰竭的早期診斷與個體化治療；心血管系統以及全身疾病導致的復雜疑難及危險重癥的分子機制、臨床診療及新藥研發；新型冠狀病毒致病機制、臨床診療路徑與藥物研發。

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1. Yang Zhang^#, Yicong Ye^#, Xiaoqiang Tang^#, Hui Wang^#, Toshiko Tanaka, Ran Tian , Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu , Ye Jin, Haiyu Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, Ruijia Dong, Luigi Ferrucci, Zhuang Tian*, Shuyang Zhang*. CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure. J Exp Med.2022;219(8): e20200418. (IF=14.31)

2. Jie Ma, Jia liu, Dunqin Gao, Xiao Li, Qiyu Zhang, Luye Lv, Yujie Wang, Jun Li, Yunping Zhu, Zhihong Wu, Hengrui Hu, Yufeng Li, Longda Ma, Qian Liu, Zhihong Hu, Shuyang Zhang,* Yiwu Zhou,* Manli Wang,* and Ling Leng*. Establishment of Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of SARS-CoV-2 Infection. Adv Sci (Weinh). 2022;9(7):e2104192. (IF=16.81)

3. Xiao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang, Jun Cai , Xiang-Dong Zhou, Dong-Po Jiang, Xiao-Chun Fei, Xue-Quan Huang, Lei Zhao, Heng Zhang, Hai-Bo Wu, Yong Ren, Zhen-Hua Liu, Hua-Rong Zhang, Cong Chen, Wen-Juan Fu1 , Heng Li, Xin-Yi Xia, Rong Chen, Yan Wang, Xin-Dong Liu, Chang-Lin Yin, Ze-Xuan Yan, Juan Wang, Rui Jing, Tai-Sheng Li, Wei-Qin Li, Chao-Fu Wang, Yan-Qing Ding, Qing Mao, Ding-Yu Zhang, Shu-Yang Zhang, Yi-Fang Ping and Xiu-Wu Bian . A cohort autopsy study defines COVID-19 systemic pathogenesis. Cell Res. 2021;31(8):836-846. (IF=25.62)

4. Qing Wu, Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen, Xianyi Liang, Jialin Xia, Pengcheng Wang, Daisuke Aibara, Shaofei Zhang,Guangyi Zeng, Chuyu Yun, Yu Yan,Yicheng Zhu, Michael Bustin, Shuyang Zhang, Frank J. Gonzalez, and Changtao Jiang. Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. J Clin Invest. 2021;131(9):e142865. (IF=14.81)

5. Wanchao Yin, Xiaodong Luan, Zhihai Li, Ziwei Zhou1, Qingxing Wang, Minqi Gao, Xiaoxi Wang , Fulai Zhou , Jingjing Shi , Erli You , Mingliang Liu , Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao , Leike Zhang*, Xuekui Yu*, Shuyang Zhang* and H. Eric Xu*. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nat Struct Mol Biol. 2021;28(3):319-325.  (IF=15.369, ESI)

6. Yan Zhang, Meng Xiao, Shulan Zhang, Peng Xia, Wei Cao, Wei Jiang, Huan Chen, Xin Ding, Hua Zhao, Hongmin Zhang, Chunyao Wang, Jing Zhao, Xuefeng Sun, Ran Tian, Wei Wu, Dong Wu, Jie Ma,  Yu Chen, Dong Zhang, Jing Xie, Xiaowei Yan, Xiang Zhou, Zhengyin Liu, Jinglan Wang, Bin Du, Yan Qin, Peng Gao, Xuzhen Qin,  Yingchun Xu, Wen Zhang, Taisheng Li, Fengchun Zhang, Yongqiang Zhao, Yongzhe Li, Shuyang Zhang, Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020;382(17):e38. (IF=91.25, C100, F1000)

7. Yang-Yang He, Yi Yan, Xin Jiang, Jun-Han Zhao, Zhe Wang, Tao Wu, Yong Wang , Shan-Shan Guo , Jue Ye, Tian-Yu Lian, Xi-Qi Xu, Jin-Lan Zhang , Kai Sun , Fu-Hua Peng, Yu-Ping Zhou , Yi-Min Mao, Xue Zhang, Ji-Wang Chen , Shu-Yang Zhang and Zhi-Cheng Jing. Spermine promotes pulmonary vascular remodelling and its synthase is a therapeutic target for pulmonary arterial hypertension. Eur Respir J. 2020;56(5):2000522. Published 2020 Nov 5. (IF=16.67)

8. Wanchao Yin^*, Chunyou Mao^*, Xiaodong Luan^*, Dan-Dan Shen^*, Qingya Shen^*, Haixia Su^*, Xiaoxi Wang , Fulai Zhou , Wenfeng Zhao , Minqi Gao , Shenghai Chang, Yuan-Chao Xie, Guanghui Tian , He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020;368(6498):1499-1504. (IF=47.73, F1000, C100, ESI)

9. Shuyang Zhang, Limeng Chen, Zongjiu Zhang, Yupei Zhao. Orphan drug development in China: progress and challenges. Lancet. 2019;394(10204):1127-1128. (IF=79.32)

10. Honghong Liu , Xi Chen , Xiaomin Hu , Haitao Niu , Ran Tian , Hui Wang , Haiyu Pang , Lingjuan Jiang, Bintao Qiu , Xiuting Chen , Yang Zhang , Yiyangzi Ma , Si Tang , Hanyu Li , Siqin Feng , Shuyang Zhang^* and Chenhong Zhang^* . Alterations in the gut microbiome and metabolism with coronary artery disease severity. Microbiome. 2019;7(1):68. Published 2019 Apr 26. (IF=14.65, C100, ESI)