車永勝，1966年生，籍貫齊齊哈爾，醫(yī)藥生物技術(shù)所研究員，博士生導(dǎo)師。1989年獲南開大學化學學士學位，1995年獲美國Clarkson大學有機化學碩士學位，2000年獲美國Iowa大學微生物藥物化學博士學位。2000年開始在OSI (Astellas)與Givaudan分別從事天然藥物與功能產(chǎn)品研發(fā)。2005年入職中科院微生物所研究員、博士生導(dǎo)師，2010年進入軍事醫(yī)學科學院毒物藥物所，2018年進入醫(yī)藥生物技術(shù)研究所。

主要從事微生物藥源分子的高效發(fā)現(xiàn)策略、產(chǎn)生途徑與機制，以及合成生物學制備技術(shù)研究。

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1. Li X,# Cui J,# Zheng W,# Zhang J,# Li R, Ma X, Lin M, Guo H, Li C, Yu X, Du P, Zhao L, He S, Lan P, Jiang J,* Che Y,* Wang L.* Bicyclol alleviates atherosclerosis by manipulating gut microbiota. Small 2022, 18(9): e2105021. (IF = 15.153).

2. Yan H,# Sun J,# Wang K,# Wang H, Wu S, Bao L, He W, Wang D, Zhu A, Zhang T, Gao R, Dong B, Li J, Yang L, Zhong M, Lv Q, Qin F,  Zhuang Z, Huang X, Yang X, Li Y,* Che Y,* Jiang J.* Repurposing CFDA-approved drug carrimycin as an antiviral agent against human coronavirsues, including the currently pandemic SARS-CoV-2. Acta Pharm Sin B 2021, 11(9): 2850-2858. (IF = 14.903)

3. Zhu S, Ren F, Guo Z, Liu J, Liu X, Liu G, Che Y.* Rogersonins A and B, imidazolone N-oxide-incorporating indole alkaloids from a verG disruption mutant of Clonostachys rogersoniana. J Nat Prod 2019, 82(2): 462–468. (IF = 4.257)

4. Liu J, Zhai Y, Zhu S, Liu G,* Che Y.* Heterologous biosynthesis of fungal sesquiterpene trichodermol in Saccharomyces cerevisiae. Front Microbiol 2018, 9: 1773. (IF = 4.259).

5. Yan S,# Liu L,# Ren F, Gao Q, Xu S, Hou B, Jiang X,* Che Y.* Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. Cell Death Dis 2017, 8: e2988. (IF = 5.638)

6. Wang L,# Feng Y,# Tian J, Xiang M, Sun J, Ding J, Yin W, Stadler M, Che Y,* Liu X.* Farming of a defensive fungal mutualist by an attelabid weevil. The ISME J 2015, 9: 1793–1801. (IF = 9.328)

7. Xiao Z,# Li L,# Li Y,# Zhou W,* Liu F, Cheng J, Liu F, Zheng P, Zhang Y,* Che Y.* Rasfonin, a novel 2-pyrone derivative, induces ras mutated Panc-1 pancreatic tumor cell death in nude mice. Cell Death Dis 2014, 5: e1241. (IF = 5.014)

8. Yuan Y,# Feng Y,# Ren F, Niu S, Liu X, Che Y.* A botryane metabolite with a new hexacyclic skeleton from an entomogenous fungus Hypocrea sp. Org Lett 2013, 15(23): 6050–6053. (IF = 6.324)

9. Li E, Zhang F, Niu S, Liu X, Liu G, Che Y.* A spiro[chroman-3,7’-isochromene]-4,6’(8’H)-dione from the Cordyceps-colonizing fungus Fimetariella sp. Org Lett 2012, 14(13): 3320–3323. (IF = 6.142)

10. Li J, Li L, Si Y, Jiang X, Guo L, Che Y.* Virgatolides A–C, benzannulated spiroketals from the plant endophytic fungus Pestalotiopsis virgatula. Org Lett 2011, 13 (10): 2670–2673. (IF = 5.862)