林東昕，1955年生，籍貫福建福州，腫瘤遺傳學(xué)和基因組學(xué)專家，腫瘤醫(yī)院研究員，博士生導(dǎo)師。1976年進(jìn)入上海醫(yī)科大學(xué)公共衛(wèi)生專業(yè)，1980年畢業(yè)。1983年在北京醫(yī)科大學(xué)公共衛(wèi)生專業(yè)攻讀碩士學(xué)位，從事食品衛(wèi)生與毒理學(xué)研究。1988年在WHO國(guó)際癌癥研究機(jī)構(gòu)（法國(guó)里昂）從事腫瘤病因?qū)W研究。1990年進(jìn)入美國(guó)國(guó)家毒理學(xué)研究中心作為高級(jí)訪問(wèn)學(xué)者進(jìn)行研究工作，主要研究腫瘤病因和腫瘤分子流行病。1994年回國(guó)工作，1995年為副研究員/副教授，1997年為研究員/教授。2013年當(dāng)選中國(guó)工程院院士。

主要研究我國(guó)常見(jiàn)惡性腫瘤（食管癌和胰腺癌等）基因組的遺傳和表遺傳學(xué)改變；這些改變與腫瘤發(fā)生發(fā)展及其表型的關(guān)系、在精準(zhǔn)防治和早篩中的作用。

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1.Deng S#, Zhang J#, Su J#, Zuo Z#, Zeng L, Liu K, Zheng Y, Huang X, Bai R, Zhuang L, Ye Y, Li M, Pan L, Deng J, Wu G, Li R, Zhang S, Wu C, Lin D*, Chen J*, Zheng J*. RNA m6A regulates transcription via DNA demethylation and chromatin accessibility. Nat Genet. 2022 Sep;54(9):1427-1437. (IF=41.307)

2. Xi Y#, Lin Y#, Guo W#, Wang X, Zhao H, Miao C, Liu W, Liu Y, Liu T, Luo Y, Fan W, Lin A, Chen Y, Sun Y, Ma Y, Niu X, Zhong C, Tan W, Zhou M, Su J*, Wu C*, Lin D*. Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma. Signal Transduction and Target Therapy, 2022;7:896–908. (IF=38.104)

3. Liu W#, Miao C#, Zhang S#, Liu Y, Niu X, Xi Y, Guo W, Chu J, Lin A, Liu H, Yang X, Chen X, Zhong C, Ma Y, Wang Y, Zhu S, Liu S, Tan W, Lin D*, Wu C*.VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance. Signal Transduction and Target Therapy, 2021;6:2906–2919. (IF=38.104)

4. Li R#, Di L#, Li J#, Fan W#, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C* (2021). A body map of somatic mutagenesis in morphologically normal human tissues. Nature 2021;597:398–403. (IF=69.504)

5. Zhang J#, Bai R#, Li M#, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, Pan L, Zheng Y, Su J, Ye Y, Fu Z, Zheng S, Zuo Z, Liu Z, Zhao Q, Che X, Xie D, Jia W, Zeng M, Tan W, Chen R*, Xu R*, Zheng J*, Lin D*. Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nature Communications 2019;10:1858. (IF=12.121)

6. Zhao Y#, Wei L#, Shao M, Huang X, Chang J, Chang J, Chu J, Cui Q, Peng L, Lou Y, Tan W, Tan WL, Lin D*, Wu C*. BRCA1 associated protein increases invasiveness of esophageal squamous-cell carcinoma. Gastroenterology 2017;153:1304–19. (IF=18.392)

7. Zheng J#, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Hang Y, Wang C, Che X, Zhou Y, Miao X, Jiang G, Yu X, Yong X, Cao G, Zou C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H, Wu C*, Lin D*.Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nature Genetics 2016;48:747–57. (IF=27.959)

8. Wu C#, Li D, Jia W, Hu Z, Zhou Y, Yu D, Tong T, Wang M, Lin D, Qiao Y, Zjou Y, Chang J, Zhai K, Wang M, Wei L, Tan W, Shen H, Zeng Y, Lin D*. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma patients. Nature Genetics 2013;45:632–638. (IF=35.209)

9. Wu C#, Kraft P, Zhai K, Chang J, Zhao W, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, Zeng Y, Chanock SJ, Taylor PR, Lin D*. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nature Genetics 2012;44:1090–1097. (IF=35.532)

10. Wu C#, Miao X, Huang L, Che C, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C*, Lin D*. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nature Genetics 2012;44:62–66. (IF=35.532)