呂家迪,準聘助理教授,副研究員,博士研究生導師。曾獲北京市科學技術獎自然科學獎一等獎、中國免疫學會青年學者獎,入選中國科協青年人才托舉工程。獲得國家自然科學基金優秀青年基金項目、國家自然科學基金原創探索計劃項目、國家自然科學基金面上項目等項目資助。
呂家迪
中國醫學科學院基礎醫學研究所
助理教授
2025-03-20
基礎醫學
免疫學
lvjiadi666@aliyun.com
呂家迪,準聘助理教授,副研究員,博士研究生導師。曾獲北京市科學技術獎自然科學獎一等獎、中國免疫學會青年學者獎,入選中國科協青年人才托舉工程。獲得國家自然科學基金優秀青年基金項目、國家自然科學基金原創探索計劃項目、國家自然科學基金面上項目等項目資助。
長期從事生物機械力學與腫瘤免疫的研究;利用生物機械力學原理,針對腫瘤細胞休眠、干性的物理特征以及免疫逃逸等方面,做出了系列創新性、可持續性的研究工作,發現物理的軟度是腫瘤干細胞獨特的標志,先后闡明了免疫因子和細胞外基質硬度參與調控腫瘤干細胞休眠的機制,并揭示生物機械力驅動的表觀遺傳修飾調控原始腫瘤細胞形成差異免疫原性的過程。
1.Lv J#, Si T#, Wang D#, Zhang C, Zhou Y, Yu J, Jiang Y, Wu D, Zhou L, Wang Z, Zhou N, Chen J, Wei K, Zhang H, Ma J, Tang K, Cao X,Huang B*. Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells. Immunity. 2025 Aug 5:S1074-7613(25)00327-9 (IF=26.3) 2.Lv, J#, Zhou, Y.#, Zhou, N., Wang, Z., Chen, J., Zhang, Y., Zhang, H. & Huang, B*. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci. Transl. Med. 15, eabq6024 (IF=17.1) 3.Lv J#, Liu Y.#, Mo S.#, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B*. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72. (IF=11.0) 4.Lv, J#, Liu, Y.#, Cheng, F.#, Li, J., Zhou, Y., Zhang, H., Xie, J., Fang, Y., Zhang, H., Wang, N., Liu, Y. & Huang, B*. Cell softness regulates tumorigenicity and stemness of cancer cells. EMBO J. 40, e106123 (IF=28.2) 5.Lv, J#, Liu, X.#, Zhou, Y.#, Cheng, F., Chen, H., Zhou, N., Chen, J. & Huang, B*. YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation. Research 6, 0215 (IF=22.0) 6.Lv, J#, Wang, Z.#, Qu, Y.#, Zhu, H., Zhu, Q., Tong, W., Liu, J., Liu, Y., Qin, C*. & Huang, B*. Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages. Cell Discov. 7, 24 (IF=38.1) 7.Lv, J#, Yu, P.#, Wang, Z., Deng, W., Bao, L., Tong, W. M., Liu, Y., Qin, C. * & Huang, B*. ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques. Cell Mol. Immunol. 18, 1308-1310 (IF=22.0) 8.Wang, Z.#, Lv, J.#, Yu, P., Qu, Y., Zhou, Y., Liu, J., Tong, W. M., Qin, C. * & Huang, B*. SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol. Immunol. 19, 210-221 (IF=14.0) 9.Liu, Y.#, Lv, J.#, Liu, J., Li, M., Xie, J., Qin, C., Tong, W. M. & Huang, B*. Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19. Cell Res. 30, 1078-1087 (IF=25.6). 10.Liu, Y.#, Lv, J.#, Liu, J.#, Liang, X., Jin, X., Zhang, H., Hu, Z. W., Cao, X., Qin, F. X. & Huang, B. * STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J. Clin. Invest. 128, 1057-1073 (IF=13.3)久久综合九色欧美综合狠狠_伊人热热久久原色播放WWW_成A人片亚洲日本久久_久久不见久久见免费影院www日本_97久久精品人人做人人爽,又色又爽又黄的视频在线观看,狼群影院视频在线观看高清版,亚洲AV无码精品网站性色,国产乱码久久久久久红粉影视,精品国产乱码久久久久久一区二区,国产精品免费视频网站,国产A级毛片久久久久久精品,一级特黄高清aaaa大片,亚洲中文字幕欧美一区,久久精品国产99久久狂热,黑人巨大精品欧美_黑人巨大精品欧美黑寡妇_黑人巨大精品欧美一区二区_黑人巨大精品欧美一区二区免费_黑人巨大跨种族video_黑人巨大无码中文字幕无码_黑人巨茎大战俄罗斯美女_黑人巨茎大战俄罗斯美女,中文字幕av不卡|亚洲欧美国产另类|天天干在线播放|日韩黄视频|欧美七区|可以免费看毛片的网站|黄色片在线|国产精品96久久久久久