文禮，研究員，博士生導師。曾獲上海市青年拔尖人才、青年東方學者和浦江人才等人才稱號，曾獲“十大醫學新銳”，曾獲美國胃腸病學會、美國胰腺病學會青年學者獎。獲得國家自然科學基金優秀青年科學基金（青B）等項目資助。
     院校引進人才，2022年加入院校。曾于2015-2018年在美國匹茲堡大學醫學院進行博士后訓練。2019年1月加入上海交通大學附屬第一人民醫院任獨立PI并先后聘為副研究員和研究員（2021年，破格）。2022年9月入職北京協和醫院。

本課題組長期致力于胰腺炎相關研究，聚焦于發病機制解析與早期干預靶點探索、胰腺損傷后修復機制、纖維化及炎-癌轉化過程中的免疫調控，以及高脂血癥型胰腺炎重癥化與復發的臨床與基礎研究。以通訊或第一作者（含共同）在領域內權威期刊發表論文30余篇，包括Gastroenterology、American Journal of Gastroenterology、Cell Communication and Signaling、Function(Oxf)、JCI insight、British Journal of Pharmacology、Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease等國際知名期刊。

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1. Bin Li#, Xiuli Zhang#, Song Liu, Xiaoyu Guo, Wanyi Lu, Kaixin Peng, Liu R, Zhigao Chen, Liang Li, Guoyong Hu, Sohail Z. Husain, Xingpeng Wang*, Li Wen*（最后通訊作者）. AXL and MERTK facilitate tissue repair in severe acute pancreatitis via a CCR5-dependent neutrophil and macrophage crosstalk. Cell Communication and Signaling. 23, 388 (2025). (IF=8.9)

2. Hanzhang Deng#, Kaixin Peng#, Liang Zhang, Jiongdi Lu, Wentong Mei, Xiaolei Shi, Yunpeng Peng, Kedong Xu, Haoxuan Li, Zheng Wang, Lu G, Wang G, Guotao, Lu, Feng Cao*, Li Wen*（最后通訊作者）. Clinical Outcomes in A Multi-Center Cohort Involving 919 Patients with Hypertriglyceridemia-associated Acute Pancreatitis. The American Journal of Gastroenterology 120(10):p 2405-2414 (IF=7.6)

3. Mengya Niu#, Xiuli Zhang#, Zengkai Wu, Bin Li, Jingpiao Bao, Juanjuan Dai, Zihan Yang, Yue Zeng, Liang Li, Stephen Pandol, Robert Sutton, Li Wen（獨立通訊作者）. Neutrophil-specific orai1 calcium channel inhibition reduces pancreatitis-associated acute lung injury. Function (Oxf) 2024;5(1): zqad061. doi: 10.1093/function/zqad061. (IF=6.2)

4. Mengya Niu, Xiuli Zhang, Pengli Song, Liang Li, Li Wen（獨立通訊作者）. Intraductal pressure in experimental models of acute and chronic pancreatitis in mice. Pancreatology 2022; 22(7):917-924.(IF=3.6)

5. Jingpiao Bao#, Xiuli Zhang#, Bin Li, Mengya Niu, Zengkai Wu, Pengli Song, Xiaoyu Guo, Liang Li, Guoyong Hu*, Li Wen*（最后通訊作者）. AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via selectively limiting CXCL2-related neutrophil infiltration. BBA -Molecular Basis of Disease 1868(12):166490. (IF=6.2)

6. Juanjuan Dai#, Mingjie Jiang#, Yangyang Hu#, Jingbo Xiao, Bin Hu, Jiyao Xu, Xiao Han, Shuangjun Shen, Bin Li, Zengkai Wu, Yan He, Yingchun Ren, Li Wen*（共同通訊作者）, Xingpeng Wang*, Guoyong Hu*. Dysregulated SREBP1c/miR-153 signaling induced by hypertriglyceridemia worsens acute pancreatitis and delays tissue repair. JCI Insight. 2021; 6(2). (IF=9.484)

7. Xiao Han#, Jianbo Ni#, Zengkai Wu#, Jianghong Wu, Bin Li, Xin Ye, Juanjuang Dai, Congying Chen, Jing Xue, Rong Wan, Li Wen*（共同通訊作者）, Xingpeng Wang*, Guoyong Hu*. Myeloid-specific dopamine D2 receptor signaling controls inflammation in acute pancreatitis via inhibiting M1 macrophage. British Journal of Pharmacology. 2020; 177 (13): 2991-3008. (IF=8.739)

8. Li Wen*（第一兼共同通訊作者）, Javed TA, Dobbs AK, Brown R, Niu M, Li L, Khalid A, Barakat M, Xiao X, Yimlamai D, Konnikova L, Yu M, Byersdorfer CA, Husain SZ*. The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on Cellular Source. Gastroenterology 2020; 159 (3): 1036-1050. (IF=22.682)

9. Li Wen#（共同第一作者）, Tanveer A. Javed#, Dean Yimlamai, Amitava Mukherjee, Xiangwei Xiao, and Sohail Z. Husain. Transient high pressure in pancreatic ducts promotes inflammation and alters tight junctions via calcineurin signalling. Gastroenterology 2018; 155 (4):1250-1263.e5. (IF=19.233)

10. Li Wen（獨立第一作者）, Svetlana Voronina, Muhammad A Javed, Muhammad Awais, Peter Szatmary, Diane Latawiec, Michael Chvanov, David Collier, Wei Huang, John Barrett, Malcolm Begg, Ken Stauderman, Jack Roos, Sergey Grigoryev, Evan Roger, Jeffrey Whitten, Gonul Velicelibi, Michael Dunn, Alexei Tepikin, David. N. Criddle and Robert Sutton*. Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models. Gastroenterology 2015; 149 (2): 481-92. (IF=18.187, F1000)