葉子璐，研究員，博士生導師。2007 年考入華中科技大學生物技術專業。2011年在中國科學院生物物理研究所攻讀碩士學位。丹麥哥本哈根大學細胞與遺傳醫學博士。長期致力于基于質譜的前沿蛋白質組學技術研究。曾獲得國家自然科學基金優秀青年科學基金項目(海外)的資助。院校引進人才，2023年加入院校。曾擔任人類蛋白質組組織(HUPO)生物與疾病人類蛋白質組計劃(B/D-HPP)委員會委員、中國生物化學與分子生物學會蛋白質組學專業分會副秘書長。

長期從事基于質譜技術的蛋白質組學與糖組學方法學創新及多維組學研究，在單細胞及痕量蛋白質組學、高通量定量分析和糖基化研究等方向取得系列原創性成果。近年來，團隊開發了Chip-Tip和One-Tip等高靈敏度、高通量單細胞蛋白質組學方法，以及Glyco-DIA等糖蛋白質組學技術，顯著提升了檢測深度和精確性。研究成果發表SCI論文30余篇，其中以第一作者或通訊作者發表13篇，發表于Cell、Nature Methods（x2）、Nature Biotechnology、Nature Communications等國際著名期刊。

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1.Sabatier P, Lechner M, Guzmán UH, Beusch CM, Zeng X, Wang L, Izaguirre F, Seth A, Gritsenko O, Rodin S, Grinnemo KH, Ye Z#, Olsen JV#. Global analysis of protein turnover dynamics in single cells. Cell. 2025. 188(9):2433. (IF = 42.5)

2.Ye Z#*, Sabatier P#, van der Hoeven L, Lechner MY, Phlairaharn T, Guzman UH, Liu Z, Huang H, Huang M, Li X, Hartlmayr D, Izaguirre F, Seth A, Joshi HJ, Rodin S, Grinnemo KH, H?rning OB, Bekker-Jensen DB, Bache N, Olsen JV*. Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics. Nature Methods, 2025: 1-11. (IF = 32.1)

3.Guzman UH#, Martinez-Val A#, Ye Z#, Damoc E, Arrey TN, Pashkova A, Renuse S, Denisov E, Petzoldt J, Peterson AC, Harking F, ?stergaard O, Rydbirk R, Aznar S, Stewart H, Xuan Y, Hermanson D, Horning S, Hock C, Makarov A, Zabrouskov V, Olsen JV*. Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition. Nature Biotechnology 2024,1-12. (IF = 41.7)

4.Ye Z#*, Sabatier P#, Martin-Gonzalez J, Eguchi A, Lechner M, ?stergaard O, Xie J, Guo Y, Schultz L, Truffer R, Bekker-Jensen DB, Bache N, Olsen JV*. One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes. Nature Communications 2024, 15(1): 2474. (IF = 15.7，ESI)

5.Ye Z#, Kilic G#, Dabelsteen S#, Marinova IN, Th?fner JFB, Levann AMR, Bagdonaite I, Vakhrushev S, Brakebusch CH, Olsen J* and Wandall H*. Loss of TGF-βRII signaling induces invasive tissue growth in a human organotypic skin model. Science Signaling 2022, 15(761). (IF = 7.3)

6.Ye Z#, Batth T, Rüther PL and Olsen J. A deeper look at carrier proteome effects for single-cell proteomics. (2022) Communications Biology, 10.1038/s42003-022-03095-4 (IF = 6.55)

7.Mao Y, Wang S, Zhao Y, Konstantinidi A, Sun L, Ye Z* and Vakhrushev SY*. Systematic Evaluation of Fragmentation Methods for Unlabeled and Isobaric Mass Tag-Labeled O-Glycopeptides. (2021) Anal Chem 93:11167-11175. (IF =8.01)

8.Ye Z# and Vakhrushev SY. The Role of Data-Independent Acquisition for Glycoproteomics. (2021) Mol Cell Proteomics 20:100042. (IF = 5.91)

9.Ye Z#, Mao Y, Clausen H and Vakhrushev SY. Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries. (2019) Nat Methods 16:902-910. (IF = 30.82)

10.Zhang C#, Ye Z#, Xue P, Shu Q, Zhou Y, Ji Y, Fu Y, Wang J and Yang F. Evaluation of Different N-Glycopeptide Enrichment Methods for N-Glycosylation Sites Mapping in Mouse Brain. (2016) J Proteome Res 15:2960-8. (IF = 4.27)