姚瑤，研究員，博士研究生導師。主持國自然面上項目和醫科院創新工程項目各1項，參與國家重點研發計劃1項。 院校引進人才，2021年加入院校。曾在成都中醫藥大學基礎醫學院任講師/助理研究員（2015年9月至2018年8月）。

長期從事人類造血干細胞基因編輯與血液系統遺傳病的基因治療研究，近五年主要學術成果包括：1）率先建立人造血干細胞CRISPR文庫篩選，解析重癥先天性粒細胞減少癥機制，開發造血干細胞通用型基因治療策略；2）設計非編碼區單堿基分辨率CRISPR篩選策略，精準鑒定調控元件及致病變異；3）開發新型基因編輯工具，結合多組學數據分析致病變異及機制。研究成果獲國際同行廣泛關注和高度評價，為血液疾病治療提供了新手段、新機制、新靶點。

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1. Yao Yao^#*, Zhiwei Zhou^#, Xiaoling Wang^#, Zhirui Liu^#, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue*, Shuquan Rao*. SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution. Cell Genom 2024, Jun 17;4(7):100583.

2.Yao Yao^#, Jiaxuan Cao^#, Wentian Wang, Boya Liu, Xiaolei Pei, Lei Zhang, Shuquan Rao*. Highly Efficient One-Step Tagging of Endogenous Genes in Primary Cells Using CRISPR-Cas Ribonucleoproteins. CRISPR J 2022;5(6):843-853.

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4. Yao Yao^#, Fei Ye^#, Kailong Li^#, Peng Xu, Wenjie Tan, Quansheng Feng, Shuquan Rao*. Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Signal Transduction Targeted Ther 2021, 6(1):85.

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6. Yao Yao^#, Hongfei Song^#, Fanshuang Zhang^#, Jibin Liu, Dong Wang, Quansheng Feng, Shuquan Rao*, Cen Jiang*. Genetic predisposition to blood cell indices in relation to severe COVID-19. J Med Virol 2023.95(1):e28104. (IF: 12.7)

7. Shuquan Rao^#*, Yao Yao^#, Daniel E Bauer*. Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation. Genome Med 2021;13(1):41.

8. Xinwen Chen^#, Jingjing Du^#, Shaowei Yun, Chaoyou Xue*, Yao Yao*, Shuquan Rao*. Recent advances in CRISPR-Cas9-based genome insertion technologies. Mol Ther Nucleic Acids 2024;35(1):102138.