鄭文婷，研究員，博士研究生導師，研究方向聚焦于免疫細胞行為的工程化改造及腫瘤治療應用，重點圍繞“工程化方法賦能免疫細胞用于腫瘤治療”開展研究。運用小鼠和人免疫細胞治療模型、CRISPR-Cas9篩選技術等探索賦能免疫細胞的新靶點和策略，應用工程化的研究手段改造細胞療法的功能元件，利用新型生物材料靶向性改造疾病微環境，優化免疫細胞功能，改善腫瘤治療。 院校引進人才，2021年加入院校，曾在美國St. Jude Children’s Research Hospital從事博士后研究。

長期從事免疫細胞治療腫瘤的研究，針對現行的細胞療法易復發、患者生存率低等臨床問題，未來將在“免疫細胞行為的工程化改造及腫瘤治療應用”領域，充分利用多學科交叉的優勢，重點圍繞“工程化方法賦能T細胞用于腫瘤治療”開展研究，以期解決腫瘤精準治療和難治復發的難題。承擔國自然青年項目，以第一/通訊作者在 J Immunother Cancer、Blood、Leukemia、Adv Funct Mater、JACS 等刊物上發表十余篇論文，總引1700余次，獲得國際專利2項。

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1.Wei Liu#, Wei Liu#, Hesong Zou#, Lianting Chen#, Wenyang Huang, Rui lv, Yan Xu, Huimin Liu, Yin Shi, Kefei Wang, Yi Wang, Wenjie Xiong, Shuhui Deng, Shuhua Yi, Weiwei Sui, Guangxin Peng, Yueshen Ma, Huijun Wang, Lulu Lv, Jianxiang Wang, Jun Wei*, Lugui Qiu*, Wenting Zheng*, Dehui Zou*. Combinational therapy of CAR T-cell and HDT/ASCT demonstrates impressive clinical efficacy and improved CAR T-cell behavior in relapsed/refractory large B-cell lymphoma. Journal for ImmunoTherapy of Cancer, 2024 Apr 16;12(4): e008857.

2.Xiaoyan Zhang#, Kefei Wang#, Zhiyuan Gao, Zelin Wu, Wei Liu, Jisen Li, Heqi Gao, Jun Wei, Dan Ding*, Wenting Zheng*. An Aggregation-Induced Emission Molecule-Assembled Nanovaccine with Self-Adjuvanted Function for Cancer Immunotherapy, Advanced Functional Materials, 2023, 33(51): 2302118.

3. Yiming Zhang#, Zhiwen Hu, Xinxin Li, Yinghao Ding, Zhenghao Zhang, Xiangyang Zhang, Wenting Zheng*, Zhimou Yang*. Amino acid sequence determines the adjuvant potency of a D-Tetra-Peptide hydrogel, Biomaterials Science, 2022 Jun 14;10(12):3092-3098.

4. Wenting Zheng#, Jun Wei, Caitlin Zebley, Lindsay L Jones, Yogesh Dhungana, Yong-Dong Wang, Jayadev Mavuluri, Lingyun Long, Yiping Fan, Benjamin Youngblood, Hongbo Chi, Terrence L Geiger*. Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL, Blood, 2021, 138(2): 122-135.

5.Wenting Zheng#, Carol E. O'Hear, Rajshekhar Alli, Jacob H. Basham, Hossam A. Abdelsamed, Lance E. Palmer, Lindsay L. Jones, Ben Youngblood, Terrence L. Geiger*. PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells, Leukemia, 2018, 32: 1157-1167.