周家喜，1976年生，籍貫湖北鶴峰，干細(xì)胞生物學(xué)家，中國(guó)醫(yī)學(xué)科學(xué)院血液病醫(yī)院（中國(guó)醫(yī)學(xué)科學(xué)院血液學(xué)研究所）研究員，博士生導(dǎo)師，協(xié)和學(xué)者特聘教授，國(guó)家杰出青年基金獲得者。1998年從華中農(nóng)業(yè)大學(xué)獲得學(xué)士學(xué)位，2001年在中國(guó)農(nóng)業(yè)科學(xué)院研究生院獲得碩士學(xué)位，2004年在中國(guó)科學(xué)院動(dòng)物研究所獲得博士學(xué)位。2005-2010年先后在美國(guó)Stowers醫(yī)學(xué)研究所和伊利諾伊大學(xué)進(jìn)行博士后研究。2010年回國(guó)加入實(shí)驗(yàn)血液學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室，2011年成為研究員。

主要研究生理和病理?xiàng)l件下巨核細(xì)胞和血小板的發(fā)生和功能改變，以及它們?cè)诟鞣N血液病及相關(guān)疾病中的意義。同時(shí)探索利用多能干細(xì)胞規(guī)模化生產(chǎn)血小板用于輸注的應(yīng)用研究，開(kāi)發(fā)血小板相關(guān)診斷和治療系列產(chǎn)品。

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1. Changlu Xu#, Jian He#, Hongtao Wang#, Yingnan Zhang#, Jing Wu#, Lu Zhao#, Yue Li, Jie Gao, Guangfeng Geng, Bingrui Wang, Xiaoyuan Chen, Zhaofeng Zheng, Biao Shen, Yang Zeng, Zhijie Bai, Hua Yang, Shujuan Shi, Fang Dong, Shihui Ma, Erlie Jiang, Tao Cheng, Yu Lan*, Jiaxi Zhou*, Bing Liu*, Lihong Shi*. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Nature Immunology. 2022 Jul;23(7):1109-1120. (IF=31.25)

2. Yiying Liu#, Jingjing Zhao , Yan Wang, Pei Su, Hongtao Wang, Cuicui Liu*, Jiaxixi Zhou*.Augmented Production of Platelets From Cord Blood With Euchromatic Histone Lysine Methyltransferase Inhibition. Stem Cells Trans Med. 2022 Jul 26;szac048. (IF= 7.655)

3. Cuicui Liu#, Dan Wu#, Meijuan Xia#, Minmin Li, Zhiqiang Sun, Biao Shen, Yiying Liu,Erlie Jiang, Hongtao Wang, Pei Su, Lihong Shi, Zhijian Xiao, Xiaofan Zhu, Wen Zhou,Qianfei Wang, Xin Gao*, Tao Cheng*,and Jiaxi Zhou* Characterization of Cellular Heterogeneity and an Immune Subpopulation of Human Megakaryocytes. Advanced Science. 2021 Aug;8(15):e2100921. (IF= 17.521)

4. Hongtao Wang#, Jian He#, Changlu Xu#, Xiaoyuan Chen#, Hua Yang#, Shujuan Shi, Cuicui Liu, Yang Zeng, Dan Wu, Zhijie Bai, Mengge Wang, Yuqi Wen, Pei Su, Meijuan Xia, Baiming Huang, Chunyu Ma,Lihong Bian, Yu Lan, Tao Cheng, Lihong Shi,* Bing Liu, * Jiaxi Zhou* Decoding Human Megakaryocyte Development .Cell Stem Cell. 2021 Mar 4;28(3):535-549.

5. Hongtao Wang#,, Mengge Wang#, Yuqi Wen#, Changlu Xu, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Tao Cheng, Lihong Shi*, Jiaxi Zhou* Biphasic Regulation of Mesenchymal Genes Controls Fate Switches During Hematopoietic Differentiation of Human Pluripotent Stem Cells. Advanced Science. 2020 Aug 19;7(20):2001019 (IF=24.633 F1000)

6. Yu Wang#,Hongtao Wang, Jiaojiao Guo, Jie Gao, Mengge Wang, Meijuan Xia, Yuqi Wen, Pei Su,Ming Yang, Mingyao Liu, Lihong Shi, Tao Cheng, Wen Zhou, * and Jiaxi Zhou,* LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation. Cell Reports. 2020 May 5;31(5):107600. (IF=9.423)

7. Jinhua Liu#, Yapu Li#, Jingyuan Tong#, Jie Gao, Qing Guo, Lingling Zhang, Bingrui Wang, Hui Zhao,Hongtao Wang, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Osamu Tanabe, James Douglas Enge,Emery H. Bresnick, Jiaxi Zhou *& Lihong Shi* Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development. Nature Communications. 2018 Oct 22;9(1):4386. (IF=11.878)

8. Leisheng Zhang#, Hongtao Wang#,Cuicui Liu, Qingqing Wu, Pei Su, Dan Wu, Jiaojiao Guo, Wen Zhou,Yuanfu Xu, Lihong Shi, JiaxiZhou*. MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME. Stem Cell Reports. 2018 Aug 14;11(2):497-513 (IF=5.499)

9. Hongtao Wang#, Cuicui Liu#, Xin Liu#, Mengge Wang, Dan Wu, Jie Gao, Pei Su, Tatsutoshi Nakahata,Wen Zhou, Yuanfu Xu, Lihong Shi, Feng Ma*, Jiaxi Zhou* MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryocyte Polyploidization and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1. Stem Cell Reports. 2018 Feb 13;10(2):447-460. (IF=5.499)

10.Wu Q#, Zhang L, Su P, Lei X, Liu X,Wang H, Lu L, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Han M, Xu Y, Wang F, Zhou J*. MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell Res. 2015 Dec;25(12):1314-32. (IF=14.812)