孫永匯，研究員，博士生導師。2012年獲得山東大學藥學專業學士學位，2018年獲得清華大學生物學專業博士學位。從事新型臨床難成藥/耐藥靶點降解劑（PROTACs）開發及分子膠新技術研究。獲得國家自然科學基金青年科學基金項目、北京市科技新星計劃項目、清華大學“水木學者”計劃資助。
     院校引進人才，2022年加入院校，曾在哈佛大學醫學院、清華大學藥學院開展研究工作，從事新型耐藥蛋白降解機制探索和新型PROTAC/分子膠雙機制蛋白降解劑研究。

長期從事新型靶向嚴重疾病相關蛋白降解PROTAC及分子膠新技術研究。開發了靶向臨床耐藥突變型BTKC481S蛋白降解劑，克服了臨床一線藥物ibrutinib的耐藥性和毒副作用；設計并獲得了靶向MELK蛋白降解劑及新型PROTAC/分子膠雙機制降解劑；開發了可見光控分子膠降解劑，顯著提高了癌癥治療效率并降低了傳統治療方案的毒性。主持2項國家級和省部級科研項目，在Cell Research、Leukemia、Chemical Science等雜志發表論文20余篇。主編英文PROTAC專著1部。授權抗腫瘤PROTAC專利2項。

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1. Wei Yan#, Naizhen Zhang#, Xiao Liu#, Qiyu He, Xucheng Lv, Jianghui Sun, Lili Zhuang, Yuexin Zou, Yajie Zhang, Yuhang Liang, Yanjie Wang, Siyuan Li, and Yonghui Sun*. Development of visible-light photocaged molecular glues (vc-MGs) for B-cell malignancies therapy with improved safety and pharmacokinetic profiles in vivo. Chinese Chemical Letters. In Press. (2025. IF=8.9)

2. Yonghui Sun*, Xiao Liu, Qiyu He, Naizhen Zhang, Wei Yan, Xucheng Lv, and Yanjie Wang. Discovery of first-in-class PROTACs targeting maternal embryonic leucine zipper kinase (MELK) for the treatment of Burkitt lymphoma. RSC Medicinal Chemistry. 15 (7):2351. (2024. IF=4.1)

3. Yonghui Sun*#, Qiyu He#, Xucheng Lv, Naizhen Zhang, Wei Yan, Jianghui Sun, and Lili Zhuang. Switchable Site-Selective Benzanilide C(sp²)-H Bromination via Promoter Regulation. Molecules. 29 (12):2861. (2024. IF=4.2)

4. Yonghui Sun, Zimo Yang, Zhimin Zhang, Zhen Li, Liubin Guo, Hao Pan, Xin Luo, Dongzhou Liu, and Yu Rao* Design, synthesis, and evaluation of BTK-targeting PROTACs with optimized bioavailability in vitro and in vivo. RSC Medicinal Chemistry. 14 (8):1562. (2023. IF=4.1)

5. Yonghui Sun#, Xin Luo#, Zimo Yang, Wenxing Lv, Lixia Chen, Hua Li*, and Yu Rao*. Developing potent BTK^C481S PROTACs for ibrutinib-resistant malignant lymphoma. Chinese Chemical Letters. 34 (6):107924. (2022. IF=9.1)

6. Zimo Yang#, Yonghui Sun#, Zhihao Ni, Celi Yang, Yan Tong, Yujie Liu, Haitao Li, and Yu Rao*. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Research. 31(12):1315-1318. (2021. IF=25.617)

7. Yonghui Sun, Yu Rao*. Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology (Chapter 8). Drug Discovery, Royal Society of Chemistry ISBN: 978-1-78801-686-5. (2020)

8. Yonghui Sun#, Ning Ding#, Yuqin Song#, Zimo Yang, Wanli Liu*, Jun Zhu*, and Yu Rao*. Degradation of Bruton’s tyrosine kinase mutants by PROTACs for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas. Leukemia 33(8):2105-2110. (2019. IF=8.665)

9. Yonghui Sun#, Xingwang Zhao#, Ning Ding#, Hongying Gao#, Yue Wu, Yiqing Yang, Meng Zhao, Jinseok Hwang, Yuqin Song, Wanli Liu*, and Yu Rao*. PROTAC-induced BTK degradation as a novel therapy for mutated BTK^C481S induced ibrutinib-resistant B-cell malignancies. Cell Research 28(7):779-781. (2018. IF=17.848, C100)

10. Yonghui Sun#, Tianyu Sun#, Yundong Wu, Xinhao Zhang*, and Yu Rao*. A diversity-oriented synthesis of bioactive benzanilides via a regioselective C(sp²)-H hydroxylation strategy. Chemical Science 7(3):2229-2238. (2016. IF=8.668)