鄧敏，研究員，博士生導師，中國醫學科學院腫瘤醫院放療科放射生物室主任，分子腫瘤學全國重點實驗室研究員，中華醫學會腫瘤放射治療分會生物學組委員。
      院校引進人才，2021年加入中國醫學科學院腫瘤醫院。2011-2021年在Mayo Clinic從事DNA損失應答相關研究，歷任Research fellow，Research Associate和Assistant professor。長期從事DNA損傷應答與腫瘤治療機制研究，主持國家自然科學基金面上項目、“2030四大慢病”國家科技重大項目子課題等。已在Trends in Cell Biology、Molecular Cell、Nature Communications、Science Advances等期刊發表論文三十余篇，被引2600余次，授權國際專利3項。

長期從事DNA損傷應答（DDR）信號通路及其在腫瘤放化療和免疫治療中的作用機制研究。重點關注腫瘤細胞DNA修復、代謝重編程與免疫微環境間的相互調控，系統解析放射抗性與治療敏感性的分子基礎。相關成果發表于Trends in Cell Biology、Molecular Cell、Cancer Research、Science Advances、Nature Communications等國際高影響力期刊，提出多條具有創新性的信號通路模型，為精準放療及放射免疫聯合治療提供了重要理論依據和潛在干預靶點。

久久综合九色欧美综合狠狠_伊人热热久久原色播放WWW_成A人片亚洲日本久久_久久不见久久见免费影院www日本_97久久精品人人做人人爽,又色又爽又黄的视频在线观看,狼群影院视频在线观看高清版,亚洲AV无码精品网站性色,国产乱码久久久久久红粉影视,精品国产乱码久久久久久一区二区,国产精品免费视频网站,国产A级毛片久久久久久精品,一级特黄高清aaaa大片,亚洲中文字幕欧美一区,久久精品国产99久久狂热,黑人巨大精品欧美_黑人巨大精品欧美黑寡妇_黑人巨大精品欧美一区二区_黑人巨大精品欧美一区二区免费_黑人巨大跨种族video_黑人巨大无码中文字幕无码_黑人巨茎大战俄罗斯美女_黑人巨茎大战俄罗斯美女,中文字幕av不卡|亚洲欧美国产另类|天天干在线播放|日韩黄视频|欧美七区|可以免费看毛片的网站|黄色片在线|国产精品96久久久久久

1．Li C^#, Zhao X^#, Li X, Wang C, Huo Z, Xu X, Kang W, Nowsheen S, Aziz K, Sun G, Liu Z*, Lou Z*, Deng M* . Targeting the ATM–TGS1–BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma. Cancer Res, 2025 (accepted); 通訊作者; SCI; IF = 16.6 (JCR 2024);

2．Yang Y#, … , Lou Z*, Deng M* . Targeting the ATM-TRMT10A-BRCA1 Axis Confers Synthetic Lethality to PARP Inhibition in Metastatic Castration-Resistant Prostate Cancer. Sci Adv, 2025; 通訊作者; SCI; IF = 12.5 (JCR 2024);

3．Xu Y#, Li C#, … , Lou Z*, Deng M* . STK39-Mediated Amplification of γ-H2AX Promotes Homologous Recombination and Contributes to PARP Inhibitor Resistance. Nucleic Acids Res, 2024; 通訊作者; SCI; IF = 13.1 (JCR 2024);

4．Xu X, Fang Y, Nowsheen S, Li YX, Lou Z*, Deng M* . Regulation of AMPK Activation by Extracellular Matrix Stiffness in Pancreatic Cancer. Genes Dis, 2023; 通訊作者; SCI; IF = 6.9 (JCR 2023);

5．Guo G^#, Gao M^#, Gao X, Zhu B, Huang J, Tu X, Kim W, Zhao F, Zhou Q, Zhu S, Wu Z, Yan Y, Zhang Y, Zeng X, Zhu Q, Yin P, Luo K, Sun J, Deng M*, Lou Z* . Reciprocal Regulation of RIG-I and XRCC4 Connects DNA Repair with RIG-I Immune Signaling. Nat Commun, 2021; 并列通訊; SCI; IF = 17.7 (JCR 2021);

6．Gao M^#, Guo G^#, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M*, Billadeau D*, Lou Z* . DOCK7 Protects Against Replication Stress by Promoting RPA Stability on Chromatin. Nucleic Acids Res, 2021; 并列通訊; SCI; IF = 19.16 (JCR 2021);

7．Deng M*, Hou J, Lou Z* . Bivalent Recognition of Histone Marks by BARD1. Trends Cell Biol, 2021; 第一作者 / 并列通訊; SCI; IF = 21.17 (JCR 2021);

8．Deng M^#, Lin J^#, Nowsheen S, Liu T, Zhao Y, Villalta PW, Sicard D, Tschumperlin DJ, Lee S, Kim J, Lou Z . Extracellular Matrix Stiffness Determines DNA Repair Efficiency and Cellular Sensitivity to Genotoxic Agents. Sci Adv, 2020; 并列一作 / 并列通訊; SCI; IF = 11.7 (JCR 2020);

9．Deng M^#, Yang X^#, Qin B^#, Liu T, Zhang H, Guo W, Lee SB, Kim JJ, Yuan J, Pei H, Wang L, Lou Z* . Deubiquitination and Activation of AMPK by USP10. Mol Cell, 2016; 第一作者; SCI; IF = 14.71 (JCR 2016); 備注：Featured Article

10．Yuan J^#, Luo K^#, Deng M^#, Li Y, Yin P, Gao B, Fang Y, Wu P, Liu T, Lou Z* . HERC2–USP20 Axis Regulates DNA Damage Checkpoint Through Claspin. Nucleic Acids Res, 2014; 并列第一作者; SCI; IF = 9.11 (JCR 2014)