張園園，研究員，課題組長，博士生導師。2015年獲得哈爾濱醫科大學生物信息學專業理學學士學位；2015-2020年在北京大學深造，獲得理學博士學位，師從國際著名生物信息學家、中國科學院院士張澤民教授，專攻腫瘤免疫微環境研究。
     院校引進人才，于2024年1月加入中國醫學科學院腫瘤醫院。2020-2023年先后在北京大學、美國麻省理工學院-哈佛大學博德研究所（Broad Institute of MIT and Harvard）和哈佛醫學院/丹娜-法伯癌癥研究所（Dana-Farber Cancer Institute）（雙聘）、德克薩斯大學MD安德森癌癥研究中心（MD Anderson Cancer Center）進行博士后研究工作。

從事單細胞功能與組學技術應用研究，在腫瘤免疫微環境解析及免疫治療機制研究領域積累了豐富經驗。開發和應用前沿生物信息學技術，深入研究腫瘤免疫微環境及免疫治療機制，關注細胞和分子異質性、表型可塑性、演化動力學，以及在腫瘤發生、進展、轉移、和耐藥等過程中癌細胞與腫瘤微環境的相互作用。

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1.Yuanyuan Zhang^#,*, Hongyan Chen^#, Hongnan Mo^#, Ning Zhao^#, Xiaoying Sun, Baolin Liu, Ranran Gao, Binghe Xu^*, Zemin Zhang^*, Zhihua Liu^*, Fei Ma^*. Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer. Cancer Cell 2025,43(3):446-463.e7. (IF= 44.5)

2.Yuanyuan Zhang^*, Zhihua Liu^*. Insights into the mechanisms of immune-checkpoint inhibitors gained from spatiotemporal dynamics of the tumor microenvironment. Advanced Science 2025,12(36):e08692. (IF= 14.1)

3.Yuanyuan Zhang^#, Hongyan Chen^#, Hongnan Mo^#, Xueda Hu^#, Ranran Gao, Yahui Zhao, Baolin Liu, Lijuan Niu, Xiaoying Sun, Xiao Yu, Yong Wang, Qing Chang, Tongyang Gong, Xiuwen Guan, Ting Hu, Tianyi Qian, Binghe Xu^*, Fei Ma^*, Zemin Zhang^*, Zhihua Liu^*. Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell 2021,39(12):1578-1593.e8. (IF= 38.585, C100)

4.Yuanyuan Zhang^*, Zemin Zhang^*. The history and advances in cancer immunotherapy: tumor-infiltrating immune cells characterization and their therapeutic implications. Cellular & Molecular Immunology 2020, 17, 807-821. (IF= 11.530, C100)

5.Yuanyuan Zhang^#, Liangtao Zheng, Lei Zhang, Xueda Hu, Xianwen Ren, Zemin Zhang^*. Deep single-cell RNA sequencing data of individual T cells from treatment-na?ve colorectal cancer patients. Scientific Data 2019, 6, 131. (IF= 8.501)

6.Fenglin Liu^#, Yuanyuan Zhang^#, Lei Zhang, Ziyi Li, Qiao Fang, Ranran Gao, Zemin Zhang^*. Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data. Genome Biology 2019, 20, 242. (IF= 10.806)

7.Xinyi Guo^#, Yuanyuan Zhang^#, Liangtao Zheng^#, Chunhong Zheng^#, Jintao Song^#, Qiming Zhang, Boxi Kang, Zhouzerui Liu, Liang Jin, Rui Xing, Ranran Gao, Lei Zhang, Minghui Dong, Xueda Hu, Xianwen Ren?, Dennis Kirchhoff, Helge Gottfried Roider, Tiansheng Yan^*, Zemin Zhang?^*. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nature Medicine 2018, 24, 978-985. (IF= 30.641, C100)

8.Lei Zhang^#, Xin Yu^#, Liangtao Zheng^#, Yuanyuan Zhang^#, Yansen Li, Qiao Fang, Ranran Gao, Boxi Kang, Qiming Zhang, Julie Y. Huang, Hiroyasu Konno, Xinyi Guo, Yingjiang Ye, Songyuan Gao, Shan Wang, Xueda Hu, Xianwen Ren, Zhanlong Shen^*, Wenjun Ouyang^*, Zemin Zhang^*. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature 2018, 564, 268-272. (IF= 43.070, C100)

9.Chunhong Zheng^#, Liangtao Zheng^#, Jae-Kwang Yoo^#, Huahu Guo^#, Yuanyuan Zhang^#, Xinyi Guo^#, Boxi Kang, Ruozhen Hu, Julie Y. Huang, Qiming Zhang, Zhouzerui Liu, Minghui Dong, Xueda Hu, Wenjun Ouyang^*, Jirun Peng^*, Zemin Zhang^*. Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing. Cell 2017, 169, 1342-1356.e16. (IF=31.398, C100)

10.Fuduan Peng^#, Ruiping Wang^#, Yuanyuan Zhang^#, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo^*, Yunyan Gu^*. Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. Molecular Cancer 2017, 1, 98. (IF= 7.776)