何蘇丹，1980年生，籍貫浙江溫州，基礎所/系統醫學研究院研究員，博士生導師。1998年考入浙江大學生物技術專業，2002年獲得學士學位。2002年在北京協和醫學院生化與分子生物學專業攻讀碩博學位，從事細胞死亡研究。2008年進入北京生命科學研究所進行博士后研究工作，主要研究細胞死亡分子機制。2010年底任蘇州大學副教授，2011年底升為教授。2018年任中國醫科院基礎所系統醫學研究中心研究員。

課題組主要研究細胞程序性死亡的分子機制及生理學、病理學意義。具體研究方向： 細胞調節性死亡的分子機制；細胞調節性死亡參與免疫調節的機理和意義；靶向細胞死亡途徑對炎癥性疾病與腫瘤的干預作用。

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1. Dou X#, Yu X#, Du S, Han Y, Li L, Zhang H, Yao Y, Du Y, Wang X, Li J, Yang T, Zhang W, Yang C, Ma F*, He S*. Interferon-mediated repression of miR-324-5p potentiates necroptosis to facilitate antiviral defense. EMBO Reports 2022, 23(8):e54438. (IF=9.071)

2. Li Z#, Hao Y#, Yang C#, Yang Q, Wu S, Ma H, Tian S, Lu H, Wang J, Yang T, He S*, Zhang X*. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. European Journal of Medicinal Chemistry 2022, 228:114036. (IF=7.088)

3. Hou J#, Ju J#, Zhang Z#, Zhao C, Li Z, Zheng J, Sheng T, Zhang H, Hu L, Yu X, Zhang W, Li Y, Wu M, Ma H*, Zhang X*, He S*. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death & Disease. 2019, 10(7):493. (IF=9.685)

4. He S*, Wang X*. RIP kinases as modulators of inflammation and immunity. Nature Immunology 2018;19(9):912-922. (IF=31.25)

5. Hu Z#, Song B#, Xu L, Zhong Y, Peng F, Ji X, Zhu F, Yang C, Zhou J, Su Y, Chen S, He Y*, He S*. Aqueous synthesized quantum dots interfere with the NF-κB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects. Biomaterials 2016, 108:187-196. (IF=15.304)

6. Dong T#, Li C#, Wang X, Dian L, Zhang X, Li L, Chen S, Cao R, Li L, Huang N, He S*, Lei X*. Ainsliadimer A selectively inhibits IKKa/b by covalently binding a conserved cysteine. Nature Communications 2015; 27;6:6522. (IF=17.694)

7. Yu X#, Li Y#, Chen Q, Su C, Zhang Z, Yang C, Hu Z, Hou J, Zhou J, Gong L, Jiang X, Zheng C*, He S*. Herpes simplex virus Type 1 (HSV-1) and HSV-2 mediate species specific modulations of programmed necrosis through the viral ribonucleotide reductase large subunit R1. Journal of Virology 2015;90(2):1088-95. (IF=6.549)

8. Wang X#, Li Y#, Liu S#, Yu X#, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S*. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proceedings of the National Academy of Sciences of the United States of America 2014;111(43):15438-43. (IF= 12.779, C100)

9. He S*, Liang Y, Shao F, Wang X*. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3 mediated pathway. Proceedings of the National Academy of Sciences of the United States of America 2011;108:20054-59. (IF= 12.779, C100)

10. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X*. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009; 137:1100-1111. (IF= 66.85, F1000, ESI, C100)