陳厚早，1978年生，安徽肥西人，基礎醫學研究所研究員，博士生導師。2001年在蚌埠醫學院獲得大學本科學位，2004年在安徽醫科大學獲得碩士學位，同年在中國協和醫科大學生物化學與分子生物學專業攻讀博士學位，2007年博士畢業后留中國醫學科學院基礎醫學院所從事心血管疾病的表觀遺傳機制研究。2011年升為副研究，2013年被破格為博士生導師，2018年升為研究員。

衰老相關心血管疾病的基礎研究，系統地闡述了表觀遺傳修飾酶SIRTuin家族等在心血管疾病中的作用，表明其可為防治心血管疾病的潛在靶點，論文被引用3800余次，H-index 35；獲2次F1000 推薦，Nat Cell Biol等5次雜志同期評論。

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1. Zheng W#*, Wang X#*, Liu J#, Yu X#, Li L, Wang H, Yu J, Pei X, Li C, Wang Z, Zhang M, Zeng X, Zhang F, Wang C, Chen H, Chen HZ*. Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes to Beh?et's disease. Proc Natl Acad Sci USA. 2022 28;119(26):e2204289119. (IF=12.779)

2. Wang X#*, Ma L#, Pei X#,Wang H, Tang X, Pei JF, Ding YN, Qu S, Wei ZY, Wang HY, Wang X, Wei GH, Liu DP*, Chen HZ*. Comprehensive assessment of cellular senescence in the tumor microenvironment. Brief Bioinform. 2022 May 13;23(3):bbac118. (IF=13.994)

3. XiaoqiangTang#,Xiao-Feng Chen#,Xin Sun#,Peng Xu,Xiang Zhao,Ying Tong,Xiao-Man Wang,Ke Yang,Yu-Tong Zhu,De-Long Hao,Zhu-Qin Zhang,De-Pei Liu*,Hou-Zao Chen*.Short-Chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis. Circulation. 2021 Mar 9;143(10):1066-1069. (IF=29.69)

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5. Xiaoqiang Tang#, Xiao-Feng Chen#, Nan-Yu Wang, Xiao-Man Wang, Shu-Ting Liang, Wei Zheng, Yun-Biao Lu, Xiang Zhao, De-Long Hao, Zhu-Qin Zhang, Ming-Hui Zou, De-Pei Liu*, Hou-Zao Chen*.SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy. Circulation. 2017 Nov 21;136(21):2051-2067.  (IF=29.69, F1000)

6. Yu-Xuan Luo#, Xiaoqiang Tang#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J.2017 May 7;38(18):1389-1398. (IF=29.983,C100)

7. Yue Liu#, Ting-Ting Wang#, Ran Zhang#, Wen-Yan Fu, Xu Wang, Fang Wang, Peng Gao, Yang-Nan Ding, Yan Xie, De-Long Hao, Hou-Zao Chen*, De-Pei Liu*.Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016 Oct 17;213(11):2473-2488. (IF=14.307)

8. Hou-Zao Chen#, Fang Wang#, Peng Gao#, Jian-Fei Pei#, Yue Liu, Ting-Ting Xu, Xiaoqiang Tang, Wen-Yan Fu, Jie Lu, Yun-Fei Yan, Xiao-Man Wang, Lei Han, Zhu-Qin Zhang, Ran Zhang, Ming-Hui Zou, De-Pei Liu*.Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Circ Res. 2016 Oct 28;119(10):1076-1088. (IF=17.367,C100)