花芳，1977年生，籍貫福建，藥物研究所研究員，博士生導(dǎo)師。1995年考入復(fù)旦大學(xué)臨床醫(yī)學(xué)專業(yè)，2000年獲醫(yī)學(xué)學(xué)士學(xué)位。本科畢業(yè)后進(jìn)入中國協(xié)和醫(yī)科大學(xué)生物化學(xué)與分子生物學(xué)專業(yè)碩博連讀，獲得理學(xué)博士學(xué)位。2005年進(jìn)入北京協(xié)和醫(yī)學(xué)院藥物研究所工作，主要從事腫瘤藥理相關(guān)研究。2017-2019年作為訪問學(xué)者在密歇根大學(xué)醫(yī)學(xué)院從事腫瘤免疫相關(guān)研究。2014年晉升副研究員，2018年晉升研究員。2021年07月獲聘北京協(xié)和醫(yī)學(xué)院準(zhǔn)聘副教授。

腫瘤對代謝因素的適應(yīng)性以及腫瘤本身的代謝方式改變是腫瘤研究的核心和重點(diǎn)。花芳團(tuán)隊(duì)一直從事腫瘤代謝與癌基因信號、以及腫瘤免疫微環(huán)境的交叉反饋調(diào)節(jié)機(jī)制、藥靶尋找以及干預(yù)策略研究。

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1. Shang S^#, Yang YW^#, Chen F^#, Yu L, Shen SH, Li K, Cui B, Lv XX, Zhang C, Yang C, Liu J, Yu JJ, Zhang XW, Li PP, Zhu ST, Zhang HZ*, Hua F*. TRIB3 Reduces CD8⁺ T Cell Infiltration and Induces Immune Evasion by Repressing the STAT1-CXCL10 Axis in Colorectal Cancer. Sci Transl Med 2022, 14(626):eabf0992. (IF=19.359)

2. Li K^#*, Zhang TT^#, Zhao CX^#, Wang F, Cui B, Yang ZN, Lv XX, Yeerjiang Z, Yuan YF, Yu JM, Wang ZH, Zhang XW, Yu JJ, Liu SS, Shang S, Huang B, Hua F*, Hu ZW*. Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability. Sci Transl Med 2021, 13(586):eabb2914. (IF=19.359)

3. Du W^#, Hua F^#, Li X, Zhang J, Li S, Wang W, Zhou J, Wang W, Liao P, Yan Y, Li G, Wei S, Grove S, Vatan L, Zgodzinski W, Majewski M, Wallner G, Chen H, Kryczek I, Fang JY, Zou W*. Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation. Cancer Discov, 2021, 11(7): 1826-1843. (IF=38.272)

4. Yu JJ^#, Zhou DD^#, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F*, Hu ZW*; TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target. Nat Commun, 2020, 11(1): 3660. (IF=14.919)

5. Yu JJ^#, Zhou DD^#, Cui B, Zhang C, Tan FW, Chang S, Li K, Lv XX, Zhang XW, Shang S, Xiang YJ, Chen F, Yu JM, Liu SS, Wang F, Hu ZW*, Hua F*. Disruption of the EGFR-SQSTM1 interaction by a stapled peptide suppresses lung cancer via activating autophagy and inhibiting EGFR signaling. Cancer Lett 2020, 474:23-35. (IF=8.679)

6. Hua F^#, Shang S^#, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW*. TRIB3 Interacts with Beta-catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology 2019, 156(3):708-721. (IF=17.373)

7. Li K^#, Zhang TT^#, Wang F, Cui B, Zhao CX, Yu JJ, Lv XX, Zhang XW, Yang ZN, Huang B, Li X, Hua F*, Hu ZW*. Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene 2018, 37(22):2967-2981. (IF=6.634)

8. Hua F^#, Li K^#, Yu JJ^#, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun 2015, 6:7951. (IF=11.329, C100)

9. Hua F^#, Shi MJ^#, Zhu XL^#, Li M, Wang HX, Yu XM, Li Y, Zhu CJ*. Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance. Biochem Pharmacol 2015, 98:224-230. (IF=5.091)

10. Hua F^#, Mu R^#, Liu JW, Xue JF, Wang ZY, Lin H, Yang HZ, Chen XG, Hu ZW*. TRB3 interacts with SMAD3 promoting tumor cell migration and invasion. J Cell Sci, 124:3235-3246, 2011. (IF: 6.111, C100)